Exploration and genome mining of natural products from marine Streptomyces
文献类型：期刊论文
| 作者 | Yang, Zhijie1; He, Jianqiao1; Wei, Xin1; Ju, Jianhua1; Ma, Junying |
| 刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2020 |
| 卷号 | 104期号:1页码:67 |
| ISSN号 | 0175-7598 |
| 关键词 | Marine microorganisms Streptomyces Genome mining Natural products |
| DOI | 10.1007/s00253-019-10227-0 |
| 英文摘要 | Marine Streptomyces sp. are an important source of bioactive compounds owing to their unique habitats and metabolic pathways. Whole-genome sequencing and bioinformatics analyses have shown that the potential of synthesizing secondary metabolites from marine-derived Streptomyces has been substantially underestimated. Genome mining is an integrated strategy used to discover natural products based on gene cluster sequences and biosynthetic pathways. Its emergence has greatly enhanced the discovery of natural compounds from marine Streptomyces, thereby yielding a large number of bioactive molecules with novel structures and potent activities. In this review, we briefly summarize the current applications of genome mining in marine Streptomyces, such as bioinformatics-based optimization of culture conditions, ribosome engineering, control of regulatory networks, heterologous expression of biosynthetic gene cluster, and combinatorial biosynthesis of natural compounds. Furthermore, we discuss the factors hindering the utilization of marine-derived natural products and conclude with the prospects for this technique. |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31870046, 81425022, U1501223, U1706206]; National Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2018A0303130005]; Special Support program for Training High-Level Talents in Guangdong [201528018] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31870046, 81425022, U1501223, U1706206]; National Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2018A0303130005]; Special Support program for Training High-Level Talents in Guangdong [201528018] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18524]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Zhijie,He, Jianqiao,Wei, Xin,et al. Exploration and genome mining of natural products from marine Streptomyces[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2020,104(1):67, 76. |
| APA | Yang, Zhijie,He, Jianqiao,Wei, Xin,Ju, Jianhua,&Ma, Junying.(2020).Exploration and genome mining of natural products from marine Streptomyces.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,104(1),67. |
| MLA | Yang, Zhijie,et al."Exploration and genome mining of natural products from marine Streptomyces".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 104.1(2020):67. |
入库方式： OAI收割
来源：南海海洋研究所
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