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Use of Ferritin Capped Mesoporous Silica Nanoparticles for Redox and pH Triggered Drug Release In Vitro and In Vivo

文献类型：期刊论文

作者Cai, Yao2,3; Deng, Tian1,3; Pan, Yongxin2; Zink, Jeffrey, I1,3
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2020-08-09
页码13
关键词drug delivery ferritin mesoporous silica nanoparticle targeting
ISSN号1616-301X
DOI10.1002/adfm.202002043
英文摘要Mesoporous silica nanoparticles (MSNs) functionalized with redox-sensitive or pH-sensitive nanovalves for doxorubicin delivery and release by using recombinant human H chain ferritin (HFn) as a cap have been designed and fabricated. In both cases, transmission electron microscope observatory, dynamic light scattering change, Fourier transform infrared spectra examination, thermogravimetric analysis show that HFn can be chemically bonded to MSNs while retaining its ability to target transferrin receptor 1 (TfR1). Cargo loading and release studies demonstrate that HFn is an efficient capping agent, blocking the pores of MSN preventing cargo molecules from diffusing out, and is responsive to redox stimuli or pH changes. More importantly, HFn can not only cap the MSNs, but also enables targeted cargo delivery to malignant cells by binding to the TfR1 that has been overexpressed in various tumors, which can be reflected by the cell viability and fluorescence microscope analysis results comparing with cyclodextrin as the capping agent and TfR1 blocking assay. The in vivo study reveals the excellent efficacy of doxorubicin loaded and HFn capped MSNs on suppression of tumor growth. The new developed drug delivery system features mutually benefit and mutually support, providing strategy for achieving specific-site therapeutics delivery systems.
WOS关键词DELIVERY SYSTEM ; H-FERRITIN ; THERAPY ; NANOCAGES ; PLATFORM ; MOXIFLOXACIN ; GATEKEEPERS ; APOFERRITIN ; NANOVALVES ; EFFICACY
资助项目National Natural Science Foundation of China[41621004] ; National Natural Science Foundation of China[41704072] ; China Postdoctoral Science Foundation[2017M610979] ; Zink Student Research Support Fund
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000557410100001
出版者WILEY-V C H VERLAG GMBH
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund
源URL[http://ir.iggcas.ac.cn/handle/132A11/97607]  
专题地质与地球物理研究所_中国科学院地球与行星物理重点实验室
通讯作者Cai, Yao; Zink, Jeffrey, I
作者单位1.Univ Calif Los Angeles, Calif Nano Syst Inst, Los Angeles, CA 90095 USA
2.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Biogeomagnetism Grp, Beijing 100029, Peoples R China
3.Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
推荐引用方式
GB/T 7714		 Cai, Yao,Deng, Tian,Pan, Yongxin,et al. Use of Ferritin Capped Mesoporous Silica Nanoparticles for Redox and pH Triggered Drug Release In Vitro and In Vivo[J]. ADVANCED FUNCTIONAL MATERIALS,2020:13.
APA Cai, Yao,Deng, Tian,Pan, Yongxin,&Zink, Jeffrey, I.(2020).Use of Ferritin Capped Mesoporous Silica Nanoparticles for Redox and pH Triggered Drug Release In Vitro and In Vivo.ADVANCED FUNCTIONAL MATERIALS,13.
MLA Cai, Yao,et al."Use of Ferritin Capped Mesoporous Silica Nanoparticles for Redox and pH Triggered Drug Release In Vitro and In Vivo".ADVANCED FUNCTIONAL MATERIALS (2020):13.

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来源：地质与地球物理研究所

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