中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 计算技术研究所
  3. 中国科学院计算技术研究所
  4. 中国科学院计算技术研究所期刊论文
  5. 英文
Study protocol for a parallel-group, double-blinded, randomized, controlled, noninferiority trial: the effect and safety of hybrid electroconvulsive therapy (Hybrid-ECT) compared with routine electroconvulsive therapy in patients with depression

文献类型：期刊论文

作者Rong, Han1,2; Xu, Shu-xian1,3; Zeng, Jing1; Yang, Ying-jia1; Zhao, Jie1; Lai, Wen-tao1; Chen, Li-chang4; Deng, Wen-feng5; Zhang, Xiangyang6; Zhang, Ying-li1
刊名BMC PSYCHIATRY
出版日期2019-11-06
卷号19期号:1页码:9
关键词Study protocol Randomized controlled trial Hybrid electroconvulsive therapy Electroconvulsive therapy Depression
DOI10.1186/s12888-019-2320-3
英文摘要BackgroundElectroconvulsive therapy (ECT) is the most rapid and effective treatment for patients with depression, ECT can achieve remarkable antidepressant effects in the initial 3-4 sessions, but significant side effects limit its use. However, recent low-charge electrotherapy (LCE) studies have demonstrated antidepressant or antipsychotic effects with significantly fewer side effects. The aim of this study is to propose a novel two-step charge set strategy for ECT treatment, referred to as Hybrid-ECT, to decrease side effects by using a low charge while preserving treatment efficacy.Methods/designA randomized, double-blinded, standard-controlled, parallel-group design will be carried out. We plan to enroll 112 inpatients diagnosed with depression (unipolar or bipolar) and randomly assign them to conventional ECT (control group) or to Hybrid-ECT (treatment group, 3 ECT sessions followed by LCE sessions (approximately 2.8 joules per session)). We will evaluate participants across a wide variety of domains including clinical symptoms, cognitive, psychological and functional metrics. We will also perform magnetic resonance imaging (MRI) and event-related potential (ERPs) assessments during treatment to explore brain function differences between ECT and LCE.DiscussionThis research proposes a simple but completely novel ECT strategy that aims to rapidly relieve depressive symptoms and minimize side effects. The mechanism of ECT and LCE will be further discussed.Trial registrationChinese Clinical Trial Registry, Number: ChiCTR1900022905 (Registration date: April 30, 2019).
资助项目Sanming Project of Medicine in Shenzhen[SZSM201812052] ; Science and Technology Program of Huizhou[2018Y128] ; Science and Technology Program of Shenzhen[JCYJ20160429190927063] ; Science and Technology Program of Shenzhen[JCYJ20170413101017457] ; Chinese National Natural Science Foundation[81201047] ; CAS Pioneer Hundred Talents Program[2017-074]
WOS研究方向Psychiatry
语种英语
出版者BMC
WOS记录号WOS:000495586100004
源URL[http://119.78.100.204/handle/2XEOYT63/14891]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Xie, Xin-hui
作者单位1.Shenzhen Kangning Hosp, Dept Psychiat, Shenzhen, Guangdong, Peoples R China
2.Jining Med Univ, Affiliated Shenzhen Clin Coll Psychiat, Jining, Shandong, Peoples R China
3.Second Peoples Hosp Huizhou, Ctr Acute Psychiat Serv, Huizhou, Guangdong, Peoples R China
4.Southern Med Univ, Sch Publ Hlth, Dept Biostat, Guangzhou, Guangdong, Peoples R China
5.Second Peoples Hosp Huizhou, Lab Brain Stimulat & Biol Psychiat, Brain Funct & Psychosomat Med Inst, Huizhou, Guangdong, Peoples R China
6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
7.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Adv Comp Res Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Rong, Han,Xu, Shu-xian,Zeng, Jing,et al. Study protocol for a parallel-group, double-blinded, randomized, controlled, noninferiority trial: the effect and safety of hybrid electroconvulsive therapy (Hybrid-ECT) compared with routine electroconvulsive therapy in patients with depression[J]. BMC PSYCHIATRY,2019,19(1):9.
APA Rong, Han.,Xu, Shu-xian.,Zeng, Jing.,Yang, Ying-jia.,Zhao, Jie.,...&Xie, Xin-hui.(2019).Study protocol for a parallel-group, double-blinded, randomized, controlled, noninferiority trial: the effect and safety of hybrid electroconvulsive therapy (Hybrid-ECT) compared with routine electroconvulsive therapy in patients with depression.BMC PSYCHIATRY,19(1),9.
MLA Rong, Han,et al."Study protocol for a parallel-group, double-blinded, randomized, controlled, noninferiority trial: the effect and safety of hybrid electroconvulsive therapy (Hybrid-ECT) compared with routine electroconvulsive therapy in patients with depression".BMC PSYCHIATRY 19.1(2019):9.

入库方式： OAI收割

来源：计算技术研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。