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CMTTdb: the cancer molecular targeted therapy database

文献类型：期刊论文

作者Bai, Xue1,2,3; Yang, Xiaobo1,2; Wu, Liangcai1,2,4,5; Zuo, Bangyou1; Lin, Jianzhen1; Wang, Shanshan1; Bian, Jin1; Sang, Xinting1; He, Yungang2; Yang, Zhen1,2
刊名ANNALS OF TRANSLATIONAL MEDICINE
出版日期2019-11-01
卷号7期号:22页码:7
关键词Molecular-targeted therapy clinical trial cancer database
ISSN号2305-5839
DOI10.21037/atm.2019.10.23
英文摘要Background: The cancer molecular targeted therapy has achieved unprecedented progress in the past decade and is thought to be the most promising direction for cancer treatment in future. As the fast growing of the clinical trials of targeted anticancer agents for different cancer types, it is critical to collect and integrate such information to guide clinical practice. Methods: We constructed the Cancer Molecular Targeted Therapy database (CMTTdb) to store and retrieve molecular targeted therapy data about randomized clinical trials (RCTs) of targeted agents and also accompanied targets, biomarkers, targeted cancer subtypes, etc. Results: Different with some existing resources, CMTTdb particularly focuses on clinical application of the trails. Design of the trails, such as treatment modalities (monotherapy or combination with other therapies), as well as results on clinical efficacy parameters, adverse events are also collected. In this current version, CMTTdb contains data for 1,088 clinical trials which cover 165 agents, 80 targets, 15 cancer types (95 molecular subtypes and 56 histological or cytological subtypes) from public literatures. This database is freely available at http://www.biosino.org/CMTTdb. A user-friendly web interface was designed so that these data can be easily retrieved. Conclusions: CMTTdb will be a valuable source for providing access to information of clinical trials on the rapidly growing number of novel targeted agent and be useful in guiding oncologists for the optimization of the therapy strategy for cancer treatment.
资助项目International Science and Technology Cooperation Projects[2016YFE0107100] ; International Science and Technology Cooperation Projects[2015DFA30650] ; CAMS Innovation Fund for Medical Science (CIFMS)[2017-I2M-4-003] ; CAMS Innovation Fund for Medical Science (CIFMS)[2018-I2M-3-001] ; Beijing Natural Science Foundation[L172055] ; Beijing Natural Science Foundation[7192158] ; Fundamental Research Funds for the Central Universities[3332018032] ; National Ten-thousand Talent Program of the Chinese Academy of Sciences[2016252] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2016252] ; Youth foundation of the national natural science foundation of China[81902620] ; Youth foundation of the national natural science foundation of China[81902353]
WOS研究方向Oncology ; Research & Experimental Medicine
语种英语
WOS记录号WOS:000500459400057
出版者AME PUBL CO
源URL[http://119.78.100.204/handle/2XEOYT63/14962]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Yang, Zhen; Zhao, Haitao
作者单位1.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Liver Surg, Beijing 100730, Peoples R China
2.Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China
3.Northern Med Univ, Clin Coll 1, Nanfang Hosp, Dept Radiol, Guangzhou 510515, Guangdong, Peoples R China
4.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China
5.Fudan Univ, Obstet & Gynecol Hosp, Dept Obstet & Gynecol, Shanghai 200090, Peoples R China
推荐引用方式
GB/T 7714		 Bai, Xue,Yang, Xiaobo,Wu, Liangcai,et al. CMTTdb: the cancer molecular targeted therapy database[J]. ANNALS OF TRANSLATIONAL MEDICINE,2019,7(22):7.
APA Bai, Xue.,Yang, Xiaobo.,Wu, Liangcai.,Zuo, Bangyou.,Lin, Jianzhen.,...&Zhao, Haitao.(2019).CMTTdb: the cancer molecular targeted therapy database.ANNALS OF TRANSLATIONAL MEDICINE,7(22),7.
MLA Bai, Xue,et al."CMTTdb: the cancer molecular targeted therapy database".ANNALS OF TRANSLATIONAL MEDICINE 7.22(2019):7.

入库方式： OAI收割

来源：计算技术研究所

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