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miRNA-192 and-215 activate Wnt/beta-catenin signaling pathway in gastric cancer via APC

文献类型：期刊论文

作者Deng, Shiqi1; Zhang, Xiaojing1,2,3; Qin, Ying4; Chen, Wangchun1; Fan, Hu1; Feng, Xianling1; Wang, Jian5; Yan, Ruibin6; Zhao, Yanqiu6; Cheng, Yulan7,8
刊名JOURNAL OF CELLULAR PHYSIOLOGY
出版日期2020-09-01
卷号235期号:9页码:6218-6229
ISSN号0021-9541
关键词APC gastric cancer miRNA-192 and-215 Wnt signaling pathway
DOI10.1002/jcp.29550
英文摘要Although great progress has been made in surgical techniques, traditional radiotherapy, and chemotherapy, gastric cancer (GC) is still the most common malignant tumor and has a high mortality, which highlights the importance of novel diagnostic markers. Emerging studies suggest that different microRNAs (miRNAs) are involved in tumorigenesis of GC. In this study, we found that miRNA-192 and -215 are significantly upregulated in GC and promote cell proliferation and migration. Adenomatous polyposis coli (APC), a well-known negative regulator in Wnt signaling, has been proved to be a target of miRNA-192 and -215. Inhibition of miRNA-192 or -215 reduced the Topflash activities and repressed the expression of Wnt signaling pathway proteins, while APC small interfering RNAs reversed the inhibitory effects, suggesting that miRNA-192 and -215 activate Wnt signaling via APC. In addition, APC mediates the cell proliferation and migration regulated by miRNA-192 and -215. Furthermore, APC is downregulated in GC tissues and negatively correlated with the expression of miRNA-192 and -215. In summary, miRNA-192 and -215 target APC and function as oncogenic miRNAs by activating Wnt signaling in GC, revealing to be potential therapeutic targets.
WOS研究方向Cell Biology ; Physiology
语种英语
出版者WILEY
WOS记录号WOS:000539325100028
源URL[http://119.78.100.204/handle/2XEOYT63/15205]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Peng, Yin; Jin, Zhe
作者单位1.Shenzhen Univ, Dept Pathol, Sch Med, Guangdong Key Lab Genome Stabil & Dis Prevent, 3688 Nanhai Ave, Shenzhen 518060, Guangdong, Peoples R China
2.Shenzhen Univ, Dept Pathol, Hlth Sci Ctr, Guangdong Prov Key Lab Reg Immun & Dis, Shenzhen, Peoples R China
3.Dept Pathol, Guangdong Prov Key Lab Mol Oncol Pathol, Guangzhou, Guangdong, Peoples R China
4.Shenzhen Second Peoples Hosp, Dept Gastrointestinal Surg, Shenzhen, Guangdong, Peoples R China
5.Guangzhou Med Univ, Dept Pathol & Pathophysiol, Guangzhou, Peoples R China
6.Peking Univ, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen Grad Sch, Shenzhen, Guangdong, Peoples R China
7.Johns Hopkins Univ, Sch Med, Dept Med, GI Div, Baltimore, MD 21205 USA
8.Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA
9.Shenzhen Inst Adv Technol, Ctr High Performance Comp, Shenzhen, Guangdong, Peoples R China
10.Howard Univ, Dept Med, Washington, DC 20059 USA
推荐引用方式
GB/T 7714		 Deng, Shiqi,Zhang, Xiaojing,Qin, Ying,et al. miRNA-192 and-215 activate Wnt/beta-catenin signaling pathway in gastric cancer via APC[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2020,235(9):6218-6229.
APA Deng, Shiqi.,Zhang, Xiaojing.,Qin, Ying.,Chen, Wangchun.,Fan, Hu.,...&Jin, Zhe.(2020).miRNA-192 and-215 activate Wnt/beta-catenin signaling pathway in gastric cancer via APC.JOURNAL OF CELLULAR PHYSIOLOGY,235(9),6218-6229.
MLA Deng, Shiqi,et al."miRNA-192 and-215 activate Wnt/beta-catenin signaling pathway in gastric cancer via APC".JOURNAL OF CELLULAR PHYSIOLOGY 235.9(2020):6218-6229.

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来源：计算技术研究所

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