Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication
文献类型：期刊论文
| 作者 | Mutharasu, Gnanavel1,4; Murugesan, Akshaya1,4,5,6; Konda Mani, Saravanan7; Yli-Harja, Olli1,2,4,8; Kandhavelu, Meenakshisundaram1,3,4,5 |
| 刊名 | JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
 |
| 出版日期 | 2020-10-30 |
| 页码 | 14 |
| 关键词 | GPR17 signaling networks glioblastoma multiforme RNA-Seq protein– protein interface kinases |
| ISSN号 | 0739-1102 |
| DOI | 10.1080/07391102.2020.1841029 |
| 英文摘要 | Glioblastoma Multiforme (GBM) is one of the most aggressive malignant tumors in the central nervous system, which arises due to the failure or crosstalk in the signaling networks. GPR17, an orphan G protein-coupled receptor is anticipated to be associated with the biology of the GBM disease progression. In the present study, we have identified the differential expressions of around 170 genes along with GPR17 through the RNA-Seq analysis of 169 GBM samples. Coordinated expression patterns of all other gene products with this receptor were analysed using gene ontology and protein-protein interaction data. Several crucial signaling components and genes that play a significant role in tumor progression have been identified among which GPR17 was found to be significantly interacting with about 30 different pathways. High-throughput molecular docking of GPR17 by homology-based model against differentially expressed proteins, showed effective recognition and binding of PX, SH3, and Ig-like domains besides Gi protein. Pathways of PI3, Src, Ptdn, Ras, cytoplasmic tyrosine kinases, phospholipases, nexins and other proteins possessing these structural domains are identified as critical signaling components of the complex GBM signaling network. Our findings also provide a mechanistic insight of GPR17-T0510-3657 interaction, which potentially regulates the interaction of PX domain and helical mPTS recognition domain-containing proteins. Overall, our results demonstrate that GPR17 mediated signaling networks could be used as a therapeutic target for GBM. Communicated by Ramaswamy H. Sarma |
| 资助项目 | Center for International Mobility (CIMO) Finland[TM-13-8898] ; Center for International Mobility (CIMO) Finland[KM-14-9107] ; Center for International Mobility (CIMO) Finland[TM-15-9720] ; Finnish cultural foundation[0116947-3] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000584061400001 |
| 出版者 | TAYLOR & FRANCIS INC |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/15481]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Kandhavelu, Meenakshisundaram |
| 作者单位 | 1.Tampere Univ, BioMediTech Inst, Tampere, Finland 2.Inst Syst Biol, Seattle, WA USA 3.Tampere Univ Hosp, Sci Ctr, Tampere, Finland 4.Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland 5.Tampere Univ, Mol Signalling Lab, Fac Med & Hlth Technol, Tampere, Finland 6.Lady Doak Coll, Dept Biotechnol, Madurai, Tamil Nadu, India 7.Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr High Performance Comp, Shenzhen, Peoples R China 8.Tampere Univ, Fac Med & Hlth Technol, Computa Syst Biol Grp, Tampere, Finland |
| 推荐引用方式 GB/T 7714 | Mutharasu, Gnanavel,Murugesan, Akshaya,Konda Mani, Saravanan,et al. Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication[J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,2020:14. |
| APA | Mutharasu, Gnanavel,Murugesan, Akshaya,Konda Mani, Saravanan,Yli-Harja, Olli,&Kandhavelu, Meenakshisundaram.(2020).Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication.JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,14. |
| MLA | Mutharasu, Gnanavel,et al."Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication".JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2020):14. |
入库方式： OAI收割
来源：计算技术研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。