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Bioactive steroidal alkaloids from the fruits of Solanum nigrum

文献类型：期刊论文

作者Gu, Xin-Yue1,2; Shen, Xiao-Fei3; Wang, Lun1,2; Wu, Zhou-Wei2; Li, Fu2; Chen, Bin2; Zhang, Guo-Lin2; Wang, Ming-Kui1,2
刊名PHYTOCHEMISTRY
出版日期2018-03-01
卷号147期号:2018页码:125-131
关键词Solanum nigrum Linn. Steroidal alkaloids Anti-inflammatory activity Cytotoxic activity
ISSN号0031-9422
DOI10.1016/j.phytochem.2017.12.020
产权排序2
文献子类Article
英文摘要The investigation of the fruits of Solanum nigrum led to the isolation of four previously undescribed steroidal alkaloids, named solanine A, 7 alpha-OH khasianine, 7 alpha-OH solamargine and 7 alpha-OH solasonine, together with six known ones. The structures of the isolated compounds were elucidated unambiguously by spectroscopic. data analyses and chemical methods. Solanine A represents an unusual steroidal alkaloid with an unprecedented 6/5/6/5/5/6 hexacyclic ring system, and its structure was confirmed by X-ray single crystal diffraction analysis. Compounds 2-4 were rare naturally occurring steroidal alkaloid glycosides bearing a hydroxyl group at C-7 position. Solanine A showed the most potent inhibitory activity against the LPS-induced NO production in murine RAW264.7 macrophages with an IC50 value of 3.85 +/- 0.71 mu M and significant cytotoxicity against MGC803, HepG2 and SW480 cancer cell lines with IC50 values of 6.00 +/- 0.52 mu M, 9.25 +/- 0.49 mu M and 6.23 +/- 0.26 mu M, respectively. (C) 2018 Elsevier Ltd. All rights reserved.
学科主题Agricultural Chemistry
URL标识查看原文
WOS关键词STRUCTURAL ELUCIDATION ; ANTINEOPLASTIC AGENTS ; NMR-SPECTROSCOPY ; GLYCOSIDES ; APOPTOSIS ; CELLS ; GROWTH ; SOLAMARGINE ; PLANTS ; DAMAGE
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:000425562300011
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://210.75.237.14/handle/351003/30320]  
专题国家天然药物工程技术研究中心_天然产物研究
成都生物研究所_天然产物研究
成都生物研究所_应用与环境微生物研究
生物多样性与生态系统服务领域_中国科学院山地生态恢复与生物资源利用重点实验室
生物多样性与生态系统服务领域_生态系统恢复与生物多样性保育四川省重点实验室
国家天然药物工程技术研究中心
作者单位1.Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China;
2.Chengdu Univ, Sch Pharm & Bioengn, Chengdu 610106, Sichuan, Peoples R China;
3.Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Child, Minist Educ,Dept Paediat, Chengdu 610041, Sichuan, Peoples R China
推荐引用方式
GB/T 7714		 Gu, Xin-Yue,Shen, Xiao-Fei,Wang, Lun,et al. Bioactive steroidal alkaloids from the fruits of Solanum nigrum[J]. PHYTOCHEMISTRY,2018,147(2018):125-131.
APA Gu, Xin-Yue.,Shen, Xiao-Fei.,Wang, Lun.,Wu, Zhou-Wei.,Li, Fu.,...&Wang, Ming-Kui.(2018).Bioactive steroidal alkaloids from the fruits of Solanum nigrum.PHYTOCHEMISTRY,147(2018),125-131.
MLA Gu, Xin-Yue,et al."Bioactive steroidal alkaloids from the fruits of Solanum nigrum".PHYTOCHEMISTRY 147.2018(2018):125-131.

入库方式： OAI收割

来源：成都生物研究所

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