An organocatalytic asymmetric Mannich reaction of pyrazoleamides with cyclic trifluoromethyl ketimines: enantioselective access to dihydroquinazolinone skeletons
文献类型：期刊论文
| 作者 | Luo, Yuan1,2; Xie, Ke-Xin3; Yue, Deng-Feng1,2; Zhang, Xiao-Mei1; Xu, Xiao-Ying1; Yuan, Wei-Cheng1 |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2019-05-14 |
| 卷号 | 16期号:18页码:3372-3375 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c8ob00707a |
| 产权排序 | 2 |
| 文献子类 | Article |
| 英文摘要 | An organocatalyzed asymmetric Mannich reaction of pyrazole-amides and cyclic trifluoromethyl ketimines with a chiral bifunctional amine-squaramide as the catalyst was developed. A wide range of trifluoromethyl dihydroquinazolinone derivatives bearing adjacent quaternary and tertiary stereogenic centers were readily obtained in good to excellent yields (up to 99%) with high diastereo- and enantioselectivities (up to 99% ee and >20 : 1 dr). The large scale experiment and transformation of the product have also been demonstrated. |
| 学科主题 | Chemistry ; Analysis |
| URL标识 | 查看原文 |
| WOS关键词 | DRUG DPC 083 ; CYCLIZATION CASCADE REACTION ; MICHAEL ADDITION ; BETA,GAMMA-UNSATURATED AMIDES ; CONSTRUCTION ; ANNULATION ; DERIVATIVES ; SQUARAMIDES ; OXINDOLES ; EFFICIENT |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000433444900008 |
| 源URL | [http://210.75.237.14/handle/351003/30252]  |
| 专题 | 公共实验与分析中心 成都生物研究所_公共实验技术中心 |
| 作者单位 | 1.Chinese Acad Sci, Natl Engn Res Ctr Chiral Drugs, Chengdu Inst Organ Chem, Chengdu 610041, Sichuan, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Luo, Yuan,Xie, Ke-Xin,Yue, Deng-Feng,et al. An organocatalytic asymmetric Mannich reaction of pyrazoleamides with cyclic trifluoromethyl ketimines: enantioselective access to dihydroquinazolinone skeletons[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2019,16(18):3372-3375. |
| APA | Luo, Yuan,Xie, Ke-Xin,Yue, Deng-Feng,Zhang, Xiao-Mei,Xu, Xiao-Ying,&Yuan, Wei-Cheng.(2019).An organocatalytic asymmetric Mannich reaction of pyrazoleamides with cyclic trifluoromethyl ketimines: enantioselective access to dihydroquinazolinone skeletons.ORGANIC & BIOMOLECULAR CHEMISTRY,16(18),3372-3375. |
| MLA | Luo, Yuan,et al."An organocatalytic asymmetric Mannich reaction of pyrazoleamides with cyclic trifluoromethyl ketimines: enantioselective access to dihydroquinazolinone skeletons".ORGANIC & BIOMOLECULAR CHEMISTRY 16.18(2019):3372-3375. |
入库方式： OAI收割
来源：成都生物研究所
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