A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates
文献类型：期刊论文
| 作者 | Jiang, Guangyou1; Liu, Min1; Fang, Dongmei2; Tan, Ping1; Huang, Min1; Zhou, Taiping1; Jiang, Zhenju1; Xu, Zhihong1; Wang, Zhouyu1 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:16页码:8961-8964 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c8ra00326b |
| 产权排序 | 2 |
| 文献子类 | Article |
| 英文摘要 | An N,N-diisopropylethylamine promoted solvent-free Ramachary reductive coupling/alkylation (RRC/A) reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates has been developed. A series of 2,2-disubstituted ethyl cyanoacetates were synthesized in one pot by the RRC/A reaction of commercially available aldehydes, ethyl cyanacetates, alkyl halides and Hantzsch ester. A solvent free two step multicomponent reaction has also been developed for the preparation of 2,2-dialkylated malononitriles and 2,2-dialkylated 4-nitrophenyl acetonitriles. All the designed RRC/A products could be easily obtained with good yields by these methods. |
| URL标识 | 查看原文 |
| WOS关键词 | HANTZSCH ESTERS ; ASYMMETRIC-SYNTHESIS ; REDUCING AGENT ; TRANSFER HYDROGENATION ; KETONE ANALOGS ; ALKYLATION ; WATER ; MULTICOMPONENT ; COMBINATION ; DERIVATIVES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000426710300057 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://210.75.237.14/handle/351003/30385]  |
| 专题 | 公共实验与分析中心 成都生物研究所_公共实验技术中心 |
| 作者单位 | 1.Xihua Univ, Dept Chem, Chengdu 610039, Sichuan, Peoples R China; 2.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Guangyou,Liu, Min,Fang, Dongmei,et al. A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates[J]. RSC ADVANCES,2018,8(16):8961-8964. |
| APA | Jiang, Guangyou.,Liu, Min.,Fang, Dongmei.,Tan, Ping.,Huang, Min.,...&Wang, Zhouyu.(2018).A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates.RSC ADVANCES,8(16),8961-8964. |
| MLA | Jiang, Guangyou,et al."A base promoted one pot solvent free version of the Ramachary reductive coupling/alkylation reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates".RSC ADVANCES 8.16(2018):8961-8964. |
入库方式： OAI收割
来源：成都生物研究所
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