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Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization

文献类型：期刊论文

作者Li, Huan4; Li, Tongtong3; Li, Xiangzhen2; Wang, Guanhong1; Lin, Qiang5; Qu, Jiapeng6,7
刊名FRONTIERS IN MICROBIOLOGY
出版日期2019-07-31
卷号9页码:1745
关键词gut microbiota urbanization beta diversity network interaction environmental filtering lifestyle
ISSN号1664-302X
DOI10.3389/fmicb.2018.01745
产权排序3
文献子类Article
英文摘要Urbanization is associated with shifts in human lifestyles, thus possibly influencing the diversity, interaction and assembly of gut microbiota. However, the question regarding how human gut microbiota adapts to varying lifestyles remains elusive. To understand the relationship between gut microbiota and urbanization, we compared the diversity, interaction and assembly of gut microbial communities of herdsmen from three regions with different levels of urbanization, namely traditional herdsmen (TH), semi-urban herdsmen (SUH) and urban herdsmen (UH). The relative abundance of Prevotella decreased with the degree of urbanization (from TH to UH), whereas that of Bacteroides, Faecalibacterium, and Blautia showed an opposite trend. Although the alpha diversity measures (observed OTUs and phylogenetic diversity) of gut microbiota were unaffected by urbanization, the beta diversity (Jaccard or Bray-Curtis distances) was significantly influenced by urbanization. Metagenome prediction revealed that the gene functions associated with metabolism (i.e., carbohydrate and lipid metabolism) had significant differences between TH and UH. Network analysis showed that the modularity increased with the degree of urbanization, indicating a high extent of niche differentiation in UH. Meanwhile the trend of network density was opposite, indicating a more complex network in TH. Notably, the relative importance of environmental filtering that governed the community assembly increased with the degree of urbanization, which indicated that deterministic factors (e.g , low-fiber diet) play more important roles than stochastic factors (e.g., stochastic dispersal) in shaping the gut microbiota. A quantification of ecological processes showed a stronger signal of variable selection in UH than TH, implying that different selective pressures cause divergent gut community compositions due to urban lifestyles. Our results suggest that beta diversity, network interactions and ecological processes of gut microbiota may reflect the degree of urbanization, and highlight the adaptation of human gut microbiota to lifestyle changes.
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WOS关键词ECOLOGICAL PROCESSES ; ASSEMBLY PROCESSES ; NEUTRAL THEORY ; DIVERSITY ; COMMUNITIES ; PATTERNS ; SUCCESSION ; GRADIENTS ; SEQUENCES ; ECOSYSTEM
WOS研究方向Microbiology
语种英语
WOS记录号WOS:000440311400001
出版者FRONTIERS MEDIA SA
源URL[http://210.75.237.14/handle/351003/30201]  
专题环境治理与食品安全领域_应用与环境微生物研究
环境治理与食品安全领域_环境微生物四川省重点实验室
环境治理与食品安全领域_中国科学院环境与应用微生物重点实验室
作者单位1.Harvard Univ, Rowland Inst Harvard, Cambridge, MA 02138 USA;
2.Chinese Acad Sci, Key Lab Environm & Appl Microbiol, Environm Microbiol Key Lab Sichuan Prov, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China;
3.Zhejiang Univ Technol, Dept Appl Biol, Coll Biotechnol & Bioengn, Hangzhou, Zhejiang, Peoples R China;
4.Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;
5.Czech Acad Sci, Inst Soil Biol, Ceske Budejovice, Czech Republic;
6.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Qinghai, Peoples R China;
7.Qinghai Prov Key Lab Restorat Ecol Cold Reg, Xining, Qinghai, Peoples R China
推荐引用方式
GB/T 7714		 Li, Huan,Li, Tongtong,Li, Xiangzhen,et al. Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization[J]. FRONTIERS IN MICROBIOLOGY,2019,9:1745.
APA Li, Huan,Li, Tongtong,Li, Xiangzhen,Wang, Guanhong,Lin, Qiang,&Qu, Jiapeng.(2019).Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization.FRONTIERS IN MICROBIOLOGY,9,1745.
MLA Li, Huan,et al."Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization".FRONTIERS IN MICROBIOLOGY 9(2019):1745.

入库方式： OAI收割

来源：成都生物研究所

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