Effect of taste masking technology on fast dissolving oral film: dissolution rate and bioavailability
文献类型：期刊论文
| 作者 | Zhu, Ying5; You, Xinru6; Huang, Keqing6; Raza, Faisal5; Lu, Xin5; Chen, Yuejian1; Dhinakar, Arvind2; Zhang, Yuan3; Kang, Yang4; Wu, Jun6 |
| 刊名 | NANOTECHNOLOGY
 |
| 出版日期 | 2019-07-27 |
| 卷号 | 29期号:30页码:304001 |
| ISSN号 | 0957-4484 |
| DOI | 10.1088/1361-6528/aac010 |
| 产权排序 | 5 |
| 文献子类 | Article |
| 英文摘要 | Fast dissolving oral film is a stamp-style, drug-loaded polymer film with rapid disintegration and dissolution. This new kind of drug delivery system requires effective taste masking technology. Suspension intermediate and liposome intermediate were prepared, respectively, for the formulation of two kinds of fast dissolving oral films with the aim of studying the effect of taste masking technology on the bioavailability of oral films. Loratadine was selected as the model drug. The surface pH of the films was close to neutral, avoiding oral mucosal irritation or side effects. The thickness of a 2 cm x 2 cm suspension oral film containing 10 mg of loratadine was 100 pm. Electron microscope analysis showed that liposomes were spherical before and after re-dissolution, and drugs with obvious bitterness could be masked by the encapsulation of liposomes. Dissolution of the two films was superior to that of the commercial tablets. Rat pharmacokinetic experiments showed that the oral bioavailability of the suspension him was signihcantly higher than that of the commercial tablets, and the relative bioavailability of the suspension him was 175%. Liposomal him produced a certain amount of improvement in bioavailability, but lower than that of the suspension him. |
| 学科主题 | Applied Physics ; Condensed Matter ; Materials Science |
| URL标识 | 查看原文 |
| WOS关键词 | DRUG-DELIVERY-SYSTEM ; WATER-SOLUBLE DRUGS ; DISINTEGRATING FILMS ; QUALITY ATTRIBUTES ; ENHANCEMENT ; FORMULATION ; LORATADINE |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000433103900001 |
| 出版者 | IOP PUBLISHING LTD |
| 源URL | [http://210.75.237.14/handle/351003/30202]  |
| 专题 | 国家天然药物工程技术研究中心_天然产物研究 生物多样性与生态系统服务领域_中国科学院山地生态恢复与生物资源利用重点实验室 |
| 作者单位 | 1.Nanjing iPharma Technol Co Ltd, 68 Zhushan Rd, Nanjing 211100, Jiangsu, Peoples R China; 2.Univ Waterloo, 200 Univ Ave W, Waterloo, ON N2L 3G1, Canada 3.Third Mil Med Univ, Xinqiao Hosp, Dept Orthoped, Chongqing 400037, Peoples R China; 4.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu 610041, Sichuan, Peoples R China; 5.China Pharmaceut Univ, State Key Lab Nat Med, 24 Tongjia Xiang, Nanjing 210009, Jiangsu, Peoples R China; 6.Sun Yat Sen Univ, Sch Engn, Key Lab Sensing Technol & Biomed Instrument Guang, Guangzhou 510006, Guangdong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhu, Ying,You, Xinru,Huang, Keqing,et al. Effect of taste masking technology on fast dissolving oral film: dissolution rate and bioavailability[J]. NANOTECHNOLOGY,2019,29(30):304001. |
| APA | Zhu, Ying.,You, Xinru.,Huang, Keqing.,Raza, Faisal.,Lu, Xin.,...&Ge, Liang.(2019).Effect of taste masking technology on fast dissolving oral film: dissolution rate and bioavailability.NANOTECHNOLOGY,29(30),304001. |
| MLA | Zhu, Ying,et al."Effect of taste masking technology on fast dissolving oral film: dissolution rate and bioavailability".NANOTECHNOLOGY 29.30(2019):304001. |
入库方式： OAI收割
来源：成都生物研究所
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