Botany, ethnomedicines, phytochemistry and pharmacology of Himalayan paeony (Paeonia emodi Royle.)
文献类型：期刊论文
| 作者 | Ahmad, Mushtaq1,2; Malik, Khafsa1; Tariq, Akash5,6; Zhang, Guolin2; Yaseen, Ghulam1; Rashid, Neelam1; Sultana, Shazia1; Zafar, Muhammad1; Ullah, Kifayat3; Khan, Muhammad Pukhtoon Zada1,4 |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2019-06-28 |
| 卷号 | 220期号:2018页码:197-219 |
| 关键词 | Taxonomic validity Ethnopharmacology Traditional medicine System biology Metabolomics |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2018.04.004 |
| 产权排序 | 1 |
| 文献子类 | Review |
| 英文摘要 | Ethnopharmacological relevance: Himalayan paeony (Paeonia emodi Royle.) is an important species used to treat various diseases. This study aimed to compile the detailed traditional medicinal uses, phytochemistry, pharmacology and toxicological investigations on P. emodi. This study also highlights taxonomic validity, quality of experimental designs and shortcomings in previously reported information on Himalayan paeony. Methods: The data was extracted from unpublished theses (Pakistan, China, India and Nepal), and different published research articles confined to pharmacology, phytochemistry and antimicrobial activities using different databases through specific keywords. The relevant information regarding medicinal uses, taxonomic/common names, part used, collection and identification source, authentication, voucher specimen number, plant extracts and their characterization, isolation and identification of phytochemicals, methods of study in silico, in vivo or in vitro, model organism used, dose and duration, minimal active concentration, zone of inhibition (antimicrobial study), bioactive compound(s), mechanism of action on single or multiple targets, and toxicological information. Results: P. emodi is reported for diverse medicinal uses with pharmacological properties like antioxidant, nephroprotective, lipoxygenase inhibitory, cognition and oxidative stress release, cytotoxic, anti-inflammatory, antiepileptic, anticonvulsant, haemaglutination, alpha-chymotrypsin inhibitory, hepatoprotective, hepatic chromes and pharmacokinetics of carbamazepine expression, beta-glucuronidase inhibitory, spasmolytic and spasmogenic, and airway relaxant. Data confined to its taxonomic validity, shows 10% studies with correct taxonomic name while 90% studies with incorrect taxonomic, pharmacopeial and common names. The literature reviewed, shows lack of collection source (11 reports), without proper source of identification (15 reports), 33 studies without voucher specimen number, 26 reports lack information on authentic herbarium submission and most of the studies (90%) without validation of taxonomic names using recognized databases. In reported methods, 67% studies without characterization of extracts, 25% lack proper dose, 40% without duration and 31% reports lack information on proper controls. Similarly, only 18% studies reports active compound(s) responsible for pharmacological activities, 14% studies show minimal active concentration, only 2.5% studies report mechanism of action on target while none of the reports mentioned in silico approach. Conclusion: P. emodi is endemic to Himalayan region (Pakistan, China, India and Nepal) with diverse traditional therapeutic uses. Majority of reviewed studies showed confusion in its taxonomic validity, incomplete methodologies and ambiguous findings. Keeping in view the immense uses of P. emodi in various traditional medicinal systems, holistic pharmacological approaches in combination with reverse pharmacology, system biology, and "omics" technologies are recommended to improve the quality of research which leads to natural drug discovery development at global perspectives. |
| 学科主题 | Pharmacology ; Toxicology |
| URL标识 | 查看原文 |
| WOS关键词 | TRADITIONAL CHINESE MEDICINE ; IN-VITRO ANTIOXIDANT ; HERBAL MEDICINE ; INDIGENOUS KNOWLEDGE ; PLANT RESOURCES ; ANTIMICROBIAL ACTIVITIES ; WILDLIFE SANCTUARY ; DISTRICT BATTAGRAM ; ENZYME-INHIBITION ; SYSTEMS BIOLOGY |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000435062900020 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://210.75.237.14/handle/351003/30222]  |
| 专题 | 生物多样性与生态系统服务领域_生态研究 生物多样性与生态系统服务领域_中国科学院山地生态恢复与生物资源利用重点实验室 国家天然药物工程技术研究中心_天然产物研究 |
| 作者单位 | 1.Quaid I Azam Univ, Dept Plant Sci, Islamabad 45320, Pakistan; 2.Chengdu Inst Biol, Ctr Nat Prod Lab, Chengdu, Sichuan, Peoples R China; 3.COMSATS Inst Informat Technol, Bio Sci, Islamabad 44000, Pakistan; 4.Govt Post Grad Coll Matta, Swat 19040, Kpk, Pakistan 5.Univ Chinese Acad Sci, Beijing 100039, Peoples R China; 6.Chinese Acad Sci, Key Lab Mt Ecol Restorat & Bioresource Utilizat &, Biodivers Conservat Key Lab Sichuan Prov, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ahmad, Mushtaq,Malik, Khafsa,Tariq, Akash,et al. Botany, ethnomedicines, phytochemistry and pharmacology of Himalayan paeony (Paeonia emodi Royle.)[J]. JOURNAL OF ETHNOPHARMACOLOGY,2019,220(2018):197-219. |
| APA | Ahmad, Mushtaq.,Malik, Khafsa.,Tariq, Akash.,Zhang, Guolin.,Yaseen, Ghulam.,...&Khan, Muhammad Pukhtoon Zada.(2019).Botany, ethnomedicines, phytochemistry and pharmacology of Himalayan paeony (Paeonia emodi Royle.).JOURNAL OF ETHNOPHARMACOLOGY,220(2018),197-219. |
| MLA | Ahmad, Mushtaq,et al."Botany, ethnomedicines, phytochemistry and pharmacology of Himalayan paeony (Paeonia emodi Royle.)".JOURNAL OF ETHNOPHARMACOLOGY 220.2018(2019):197-219. |
入库方式： OAI收割
来源：成都生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。