H2O2-Responsive Nanoparticle Based on the Supramolecular Self-Assemble of Cyclodextrin
文献类型：期刊论文
| 作者 | Dong, Zhenqiang2,3; Kang, Yang1; Yuan, Qijuan2; Luo, Manli4; Gu, Zhipeng2 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2019-05-28 |
| 卷号 | 9页码:552 |
| 关键词 | responsive cyclodextrin self-assemble nanoparticle BSA |
| ISSN号 | 1663-9812 |
| DOI | 10.3389/fphar.2018.00552 |
| 产权排序 | 3 |
| 文献子类 | Article |
| 英文摘要 | Designing stimuli responsive, controllable and biocompatible multifunctional nanoparticles is an important progress in the current quest for drug delivery systems. Herein, we devoted to developing a beta-cyclodextrin (beta-CD) based drug delivery nanoparticles (NPs) that release Bovine serum albumin ( BSA) via glucose-responsive gate. The design involves synthesis of sodium alginate with beta-CD modified ( Alg-beta-CD) and methoxypolyethylene glycol (mPEG-Fc) containing ferrocene (Fc) uncharged end-capping. When alpha-cyclodextrin (alpha-CD) was added with these two segments, the stable non-covalent supramolecular structure of Alg-beta-CD/mPEG-Fc/alpha-CD can be selfassembled into NPs in aqueous solution. BSA loaded Alg-beta-CD/mPEG-Fc/alpha-CD also has been prepared. Interestingly, these supramolecular Alg-beta-CD/mPEG-Fc/alpha-CD/BSA NPs showed uniform sphere structure and constant BSA loading content. Also, this new kind of NPs can disassemble in the present of hydrogen peroxide (H2O2). Since glucose oxidase ( GOD) can oxidize glucose and produce H2O2, so this kind of polymeric NPs can also have glucose responsive behavior in the GOD containing environment. Developed functional Alg-beta-CD/mPEG-Fc/alpha-CD might be a promising drug delivery strategy for diabetes or immunotherapy with more efficiency. |
| URL标识 | 查看原文 |
| WOS关键词 | CANCER-THERAPY ; DOXORUBICIN DELIVERY ; RELEASE ; PRODRUGS ; CARRIERS ; SYSTEM ; PH |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000433185100001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://210.75.237.14/handle/351003/30249]  |
| 专题 | 国家天然药物工程技术研究中心_天然产物研究 生物多样性与生态系统服务领域_中国科学院山地生态恢复与生物资源利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu, Sichuan, Peoples R China; 2.Sun Yat Sen Univ, Sch Engn, Key Lab Sensing Technol & Biomed Instrument Guang, Guangzhou, Guangdong, Peoples R China; 3.Quzhou Univ, Coll Chem & Mat Engn, Quzhou, Peoples R China; 4.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Zhenqiang,Kang, Yang,Yuan, Qijuan,et al. H2O2-Responsive Nanoparticle Based on the Supramolecular Self-Assemble of Cyclodextrin[J]. FRONTIERS IN PHARMACOLOGY,2019,9:552. |
| APA | Dong, Zhenqiang,Kang, Yang,Yuan, Qijuan,Luo, Manli,&Gu, Zhipeng.(2019).H2O2-Responsive Nanoparticle Based on the Supramolecular Self-Assemble of Cyclodextrin.FRONTIERS IN PHARMACOLOGY,9,552. |
| MLA | Dong, Zhenqiang,et al."H2O2-Responsive Nanoparticle Based on the Supramolecular Self-Assemble of Cyclodextrin".FRONTIERS IN PHARMACOLOGY 9(2019):552. |
入库方式： OAI收割
来源：成都生物研究所
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