Bioactive halogenated dihydroisocoumarins produced by the endophytic fungus Lachnum palmae isolated from Przewalskia tangutica
文献类型：期刊论文
| 作者 | Zhao, Min5; Yuan, Lv-Yi4; Guo, Da-Le1; Ye, Ye5; Da-Wa, Zhuo-Ma2; Wang, Xiao-Ling4; Ma, Feng-Wei5; Chen, Lei5; Gu, Yu-Cheng3; Ding, Li-Sheng5 |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2018-04-01 |
| 卷号 | 148期号:2018页码:97-103 |
| ISSN号 | 0031-9422 |
| 关键词 | Przewalskia tangutica Solanaceae Lachnum palmae Hyaloscyphaceae Chemical epigenetic manipulation Dihydroisocoumarins |
| DOI | 10.1016/j.phytochem.2018.01.018 |
| 产权排序 | 1 |
| 文献子类 | Article |
| 英文摘要 | Guided by the UPLC-ESIMS profile, seven previously undescribed halogenated dihydroisocoumarins, palmaerones A-G, along with eleven known dihydroisocoumarins, were isolated from Lachnum palmae, an endophytic fungus from Przewalskia tangutica by exposure to a histone deacetylase inhibitor SAHA. Structures of the isolates were elucidated by analysis of their NMR, MS and optical rotation values. The antimicrobial, anti-inflammatory and cytotoxic activities of palmaerones A-G were evaluated. Palmaerones A-G showed antimicrobial activities against the strains (C. neoformans, Penicillium sp., C. albicans, B. subtilis and S. aureus), and palmaerone E exhibited potential antimicrobial activities against all the test strains with the MIC value in the range of 10-55 mu g/mL. Palmaerones A and E exhibited moderate inhibitory effects on NO production in LPS-induced RAW 264.7 cells, with the IC50 values of 26.3 and 38.7 mu M, respectively and no obvious toxicities were observed at 50 mu M. Palmaerone E showed weak cytotoxicity against HepG2 with the IC50 value of 42.8 mu M. This work provides an effective strategy for expanding natural product resource. (C) 2018 Elsevier Ltd. All rights reserved. |
| 学科主题 | Agricultural Chemistry |
| URL标识 | 查看原文 |
| WOS关键词 | HISTONE DEACETYLASE INHIBITOR ; SUBEROYLANILIDE HYDROXAMIC ACID ; ENTOMOPATHOGENIC FUNGUS ; CORDYCEPS-INDIGOTICA ; CIRCULAR-DICHROISM ; ASPERGILLUS-NIGER ; POLYKETIDE ; METABOLITES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000427334600012 |
| 源URL | [http://210.75.237.14/handle/351003/30293]  |
| 专题 | 国家天然药物工程技术研究中心_天然产物研究 生物多样性与生态系统服务领域_中国科学院山地生态恢复与生物资源利用重点实验室 |
| 作者单位 | 1.Chengdu Univ TCM, Chengdu 610041, Sichuan, Peoples R China; 2.Tibet Autonomous Reg Inst Food & Drug Control, Lhasa 850000, Peoples R China; 3.Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England 4.Southwest Univ Nationalities, Chengdu 610041, Sichuan, Peoples R China; 5.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu 610041, Sichuan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Min,Yuan, Lv-Yi,Guo, Da-Le,et al. Bioactive halogenated dihydroisocoumarins produced by the endophytic fungus Lachnum palmae isolated from Przewalskia tangutica[J]. PHYTOCHEMISTRY,2018,148(2018):97-103. |
| APA | Zhao, Min.,Yuan, Lv-Yi.,Guo, Da-Le.,Ye, Ye.,Da-Wa, Zhuo-Ma.,...&Zhou, Yan.(2018).Bioactive halogenated dihydroisocoumarins produced by the endophytic fungus Lachnum palmae isolated from Przewalskia tangutica.PHYTOCHEMISTRY,148(2018),97-103. |
| MLA | Zhao, Min,et al."Bioactive halogenated dihydroisocoumarins produced by the endophytic fungus Lachnum palmae isolated from Przewalskia tangutica".PHYTOCHEMISTRY 148.2018(2018):97-103. |
入库方式： OAI收割
来源：成都生物研究所
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