Significant Suppression of Non-small-cell Lung Cancer by Hydrophobic Poly(ester amide) Nanoparticles with High Docetaxel Loading
文献类型：期刊论文
| 作者 | Chen, Xing3; Zhao, Lili1; Kang, Yang2; He, Zhiyu3; Xiong, Fei3; Ling, Xiang3; Wu, Jun3 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2019-02-28 |
| 卷号 | 9页码:118 |
| 关键词 | cancer docetaxel hydrophobicity nanoparticle poly(ester amide) |
| ISSN号 | 1663-9812 |
| DOI | 10.3389/fphar.2018.00118 |
| 产权排序 | 3 |
| 文献子类 | Article |
| 英文摘要 | Non-small-cell lung cancer (NSCLC) accounts for over 85% of clinical lung cancer cases, which is the leading cause of cancer-related death. To develop new therapeutic strategy for NSCLC, a library of L-phenylalanine-based poly(ester amide) (Phe-PEA) polymers was synthesized and assembled with docetaxel (Dtxl) to form Dtxl-loaded Phe-PEA nanoparticles (NPs). The hydrophobic Phe-PEA polymers were able to form NPs by nanoprecipitation method and the characterization results showed that the screened Dtxl-8P4 NPs have small particle size (similar to 100 nm) and high Dtxl loading (similar to 20 wt%). In vitro experiments showed that Dtxl-8P4 NPs were rapidly trafficked into cancer cells, then effectively escaped from lysosomal degradation and achieved significant tumor cell inhibition. In vivo results demonstrated that Dtxl-8P4 NPs with prolonged blood circulation could efficiently deliver Dtxl to A549 tumor sites, leading to reduced cell proliferation, block metastasis, and increase apoptosis, then persistent inhibition of tumor growth. Therefore, Phe-PEA NPs are able to load high amount of hydrophobic drugs and could be a promising therapeutic approach for NSCLC and other cancer treatments. |
| URL标识 | 查看原文 |
| WOS关键词 | THERAPY ; ANGIOGENESIS ; PROTEINS ; EFFICACY ; DRUG |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000426294200001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://210.75.237.14/handle/351003/30326]  |
| 专题 | 国家天然药物工程技术研究中心_天然产物研究 生物多样性与生态系统服务领域_中国科学院山地生态恢复与生物资源利用重点实验室 |
| 作者单位 | 1.Jiangsu Prov Hosp, Digest Endoscopy Ctr, Nanjing, Jiangsu, Peoples R China; 2.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu, Sichuan, Peoples R China 3.Sun Yat Sen Univ, Sch Engn, Key Lab Sensing Technol & Biomed Instrument Guang, Guangzhou, Guangdong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Xing,Zhao, Lili,Kang, Yang,et al. Significant Suppression of Non-small-cell Lung Cancer by Hydrophobic Poly(ester amide) Nanoparticles with High Docetaxel Loading[J]. FRONTIERS IN PHARMACOLOGY,2019,9:118. |
| APA | Chen, Xing.,Zhao, Lili.,Kang, Yang.,He, Zhiyu.,Xiong, Fei.,...&Wu, Jun.(2019).Significant Suppression of Non-small-cell Lung Cancer by Hydrophobic Poly(ester amide) Nanoparticles with High Docetaxel Loading.FRONTIERS IN PHARMACOLOGY,9,118. |
| MLA | Chen, Xing,et al."Significant Suppression of Non-small-cell Lung Cancer by Hydrophobic Poly(ester amide) Nanoparticles with High Docetaxel Loading".FRONTIERS IN PHARMACOLOGY 9(2019):118. |
入库方式： OAI收割
来源：成都生物研究所
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