Description and initial characterization of metatranscriptomic nidovirus-like genomes from the proposed new family Abyssoviridae, and from a sister group to the Coronavirinae, the proposed genus Alphaletovirus
文献类型：期刊论文
| 作者 | Bukhari, Khulud4; Mulley, Geraldine4; Gulyaeva, Anastasia A.3; Zhao, Lanying2; Shu, Guocheng2; Jiang, Jianping2; Neuman, Benjamin W.1 |
| 刊名 | VIROLOGY
 |
| 出版日期 | 2018-11-01 |
| 卷号 | 524期号:2018页码:160-171 |
| 关键词 | Nidovirales Transcriptome Virus discovery Proteinase Protease Protein expression Translation Readthrough |
| ISSN号 | 0042-6822 |
| DOI | 10.1016/j.virol.2018.08.010 |
| 产权排序 | 3 |
| 文献子类 | Article |
| 英文摘要 | Transcriptomics has the potential to discover new RNA virus genomes by sequencing total intracellular RNA pools. In this study, we have searched publicly available transcriptomes for sequences similar to viruses of the Nidovirales order. We report two potential nidovirus genomes, a highly divergent 35.9 kb likely complete genome from the California sea hare Aplysia californica, which we assign to a nidovirus named Aplysia abyssovirus 1 (AAbV), and a coronavirus-like 22.3 kb partial genome from the ornamented pygmy frog Microhyla fissipes, which we assign to a nidovirus named Microhyla alphaletovirus 1 (MLeV). AAbV was shown to encode a functional main proteinase, and a translational readthrough signal. Phylogenetic analysis suggested that AAbV represents a new family, proposed here as Abyssoviridae. MLeV represents a sister group to the other known coronaviruses. The importance of MLeV and AAbV for understanding nidovirus evolution, and the origin of terrestrial nidoviruses are discussed. |
| 学科主题 | Microbiology |
| URL标识 | 查看原文 |
| WOS关键词 | MESSENGER-RNA ; STRUCTURAL BASIS ; READ ALIGNMENT ; SIGNAL ; TRANSCRIPTOME ; CHYMOTRYPSIN ; DOWNSTREAM ; EVOLUTION ; PROTEASE ; APLYSIA |
| WOS研究方向 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000446415700016 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://210.75.237.14/handle/351003/30128]  |
| 专题 | 食品安全与环境治理领域_中国科学院环境与应用微生物重点实验室 |
| 作者单位 | 1.Texas A&M Univ, 7101 Univ Ave, Texarkana, TX 75503 USA 2.Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China; 3.Leiden Univ, Med Ctr, Dept Med Microbiol, Leiden, Netherlands; 4.Univ Reading, Reading, Berks, England; |
| 推荐引用方式 GB/T 7714 | Bukhari, Khulud,Mulley, Geraldine,Gulyaeva, Anastasia A.,et al. Description and initial characterization of metatranscriptomic nidovirus-like genomes from the proposed new family Abyssoviridae, and from a sister group to the Coronavirinae, the proposed genus Alphaletovirus[J]. VIROLOGY,2018,524(2018):160-171. |
| APA | Bukhari, Khulud.,Mulley, Geraldine.,Gulyaeva, Anastasia A..,Zhao, Lanying.,Shu, Guocheng.,...&Neuman, Benjamin W..(2018).Description and initial characterization of metatranscriptomic nidovirus-like genomes from the proposed new family Abyssoviridae, and from a sister group to the Coronavirinae, the proposed genus Alphaletovirus.VIROLOGY,524(2018),160-171. |
| MLA | Bukhari, Khulud,et al."Description and initial characterization of metatranscriptomic nidovirus-like genomes from the proposed new family Abyssoviridae, and from a sister group to the Coronavirinae, the proposed genus Alphaletovirus".VIROLOGY 524.2018(2018):160-171. |
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来源：成都生物研究所
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