The right thalamus may play an important role in anesthesia-awakening regulation in frogs
文献类型：期刊论文
| 作者 | Fan, Yanzhu3,4; Yue, Xizi1,3; Xue, Fei3; Brauth, Steven E.2; Tang, Yezhong3; Fang, Guangzhan1,3 |
| 刊名 | PEERJ
 |
| 出版日期 | 2019-03-15 |
| 卷号 | 6页码:e4516 |
| 关键词 | General anesthesia Thalamus Xenopus laevis Approximate entropy (ApEn) Lateralization Permutation entropy (PE) |
| ISSN号 | 2167-8359 |
| DOI | 10.7717/peerj.4516 |
| 产权排序 | 1 |
| 文献子类 | Article |
| 英文摘要 | Background. Previous studies have shown that the mammalian thalamus is a key structure for anesthesia-induced unconsciousness and anesthesia-awakening regulation. However, both the dynamic characteristics and probable lateralization of thalamic functioning during anesthesia-awakening regulation are not fully understood, and little is known of the evolutionary basis of the role of the thalamus in anesthesia-awakening regulation. Methods. An amphibian species, the South African clawed frog (Xenopus laevis) was used in the present study. The frogs were immersed in triciane methanesulfonate (MS-222) for general anesthesia. Electroencephalogram (EEG) signals were recorded continuously from both sides of the telencephalon, diencephalon (thalamus) and mesencephalon during the pre-anesthesia stage, administration stage, recovery stage and post-anesthesia stage. EEG data was analyzed including calculation of approximate entropy (ApEn) and permutation entropy (PE). Results. Both ApEn and PE values differed significantly between anesthesia stages, with the highest values occurring during the awakening period and the lowest values during the anesthesia period. There was a significant correlation between the stage durations and ApEn or PE values during anesthesia-awakening cycle primarily for the right diencephalon (right thalamus). ApEn and PE values for females were significantly higher than those for males. Discussion. ApEn and PE measurements are suitable for estimating depth of anesthesia and complexity of amphibian brain activity. The right thalamus appears physiologically positioned to play an important role in anesthesia-awakening regulation in frogs indicating an early evolutionary origin of the role of the thalamus in arousal and consciousness in land vertebrates. Sex differences exist in the neural regulation of general anesthesia in frogs. |
| URL标识 | 查看原文 |
| WOS关键词 | CROSS-APPROXIMATE ENTROPY ; POSITRON-EMISSION-TOMOGRAPHY ; GENERAL-ANESTHESIA ; PERMUTATION ENTROPY ; BURST SUPPRESSION ; SPECTRAL EDGE ; BRAIN ; PROPOFOL ; DEPTH ; BEHAVIOR |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000427655800006 |
| 出版者 | PEERJ INC |
| 源URL | [http://210.75.237.14/handle/351003/30299]  |
| 专题 | 食品安全与环境治理领域_中国科学院环境与应用微生物重点实验室 |
| 作者单位 | 1.China West Normal Univ, Coll Life Sci, Nanchong, Sichuan, Peoples R China; 2.Univ Maryland, Dept Psychol, College Pk, MD 20742 USA 3.Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China; 4.Univ Chinese Acad Sci, Beijing, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Fan, Yanzhu,Yue, Xizi,Xue, Fei,et al. The right thalamus may play an important role in anesthesia-awakening regulation in frogs[J]. PEERJ,2019,6:e4516. |
| APA | Fan, Yanzhu,Yue, Xizi,Xue, Fei,Brauth, Steven E.,Tang, Yezhong,&Fang, Guangzhan.(2019).The right thalamus may play an important role in anesthesia-awakening regulation in frogs.PEERJ,6,e4516. |
| MLA | Fan, Yanzhu,et al."The right thalamus may play an important role in anesthesia-awakening regulation in frogs".PEERJ 6(2019):e4516. |
入库方式： OAI收割
来源：成都生物研究所
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