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Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon gamma-activated murine macrophages and animal models of inflammation

文献类型：期刊论文

作者Zhao, Lin1; Wang, Lun4; Di, Suo-ni2; Xu, Qian3; Ren, Qing-cuo1; Chen, Shan-ze3; Huang, Ning3; Jia, Da1; Shen, Xiao-fei1
刊名BIOMEDICINE & PHARMACOTHERAPY
出版日期2018-09-01
卷号105期号:2018页码:606-615
关键词Solanine A Solanum nigrum Linn. Anti-inflammatory activity NF-kappa B and MAPKs cascades PI3K/Akt and JAK/STATs signalings
ISSN号0753-3322
DOI10.1016/j.biopha.2018.06.019
产权排序2
文献子类Article
英文摘要Solanine A is a novel steroidal alkaloid isolated from Solarium nigrum Linn., a medicinal and edible plant which is widely used for treating various inflammatory diseases. In this study, we found that solanine A markedly suppressed the production of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) in lipopolysaccharide/interferon-gamma (LPS/IFN gamma)-stimulated RAW264.7 cells, and attenuated xylene, carrageenan and agar-induced inflammation in mice. The mRNA levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and -1 beta (IL-1 beta), as well as C-X-C motif chemokine ligand-9 (CXCL9), were significantly decreased by solanine A. Furthermore, solanine A also suppressed LPS/IFN gamma-induced protein expression of iNOS and COX2. Mechanistically, solanine A inhibited the nuclear translocation of nuclear factor-kappa B (NF-kappa B) through the prevention of NF-kappa B p65 and inhibitory kappa B-alpha (I kappa B alpha) phosphorylation and I kappa B alpha degradation, and it also suppressed activation of extracellular regulated protein kinases (ERK), signal transducers and activators of transcription-1 (STAT1) and serine/threonine protein kinase Akt in LPS/IFN gamma-stimulated RAW264.7 macrophages and agar-induced granuloma model in mice. Taken together, solanine A exhibits a potent antiinflammatory activity in LPS/IFN gamma- activated macrophages and animal models of inflammation through inhibition of NF-kappa B, ERK1/2, Akt and STAT1 signaling pathways, suggesting that solanine A may be a valuable leading compound in the treatment of inflammatory diseases.
学科主题Pharmacology ; Toxicology
URL标识查看原文
WOS关键词NF-KAPPA-B ; SIGNALING PATHWAYS ; ALPHA-TOMATINE ; HUMAN-DISEASE ; INHIBITION ; POLARIZATION ; ANTIOXIDANT ; MECHANISMS ; EXPRESSION ; VEGETABLES
WOS研究方向Research & Experimental Medicine ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000438312600069
出版者ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
源URL[http://210.75.237.14/handle/351003/30162]  
专题国家天然药物工程技术研究中心_天然产物研究
国家天然药物工程技术研究中心
作者单位1.Sichuan Univ, West China Univ Hosp, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Sichuan, Peoples R China;
2.Peoples Liberat Army, Hosp 451, Inst Tradit Chinese Med, Xian, Shaanxi, Peoples R China
3.Sichuan Univ, Dept Pathophysiol, West China Coll Basic & Forens Med, Chengdu, Sichuan, Peoples R China;
4.Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China;
推荐引用方式
GB/T 7714		 Zhao, Lin,Wang, Lun,Di, Suo-ni,et al. Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon gamma-activated murine macrophages and animal models of inflammation[J]. BIOMEDICINE & PHARMACOTHERAPY,2018,105(2018):606-615.
APA Zhao, Lin.,Wang, Lun.,Di, Suo-ni.,Xu, Qian.,Ren, Qing-cuo.,...&Shen, Xiao-fei.(2018).Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon gamma-activated murine macrophages and animal models of inflammation.BIOMEDICINE & PHARMACOTHERAPY,105(2018),606-615.
MLA Zhao, Lin,et al."Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon gamma-activated murine macrophages and animal models of inflammation".BIOMEDICINE & PHARMACOTHERAPY 105.2018(2018):606-615.

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来源：成都生物研究所

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