中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Direct and highly stereoselective synthesis of quinolizidine iminosugars promoted by L-proline-Et3N

文献类型:期刊论文

AuthorYuan, Wen1,2,3; Pan, Yang1,3; Zhang, Xiaoke1,3; Liang, Peng1,3; Zhang, Jichao1,3; Jiao, Wei3; Shao, Huawu3
SourceORGANIC & BIOMOLECULAR CHEMISTRY
Issued Date2019-12-21
Volume16Issue:47Pages:9230-9236
ISSN1477-0520
DOI10.1039/c8ob01953crsc.li/obc
Rank1
SubtypeArticle
English AbstractA mild and effective method for the synthesis of polyhydroxylated quinolizidine iminosugars is described. The Mannich-type reaction of iminosugar C-glycosides with aldehyde in the presence of L-proline-Et3N provides polyhydroxylated quinolizidine iminosugars, and desired products as the potential glucosidase inhibitors were obtained in good to excellent yields with excellent stereoselectivity.
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WOS KeywordGLYCOSIDASE INHIBITORS ; ASYMMETRIC-SYNTHESIS ; POLYHYDROXYLATED QUINOLIZIDINES ; 1,2-CYCLOPROPANATED SUGARS ; 1,3-DIPOLAR CYCLOADDITION ; INDOLIZIDINE ; DERIVATIVES ; EFFICIENT ; CONCISE ; CASTANOSPERMINE
WOS Research AreaChemistry
Language英语
PublisherROYAL SOC CHEMISTRY
WOS IDWOS:000452321100019
源URL[http://210.75.237.14/handle/351003/30081]  
Collection生物多样性与生态系统服务领域_两栖爬行动物科普馆
Affiliation1.Sichuan Coll Tradit Chinese Med, Mianyang, Sichuan, Peoples R China;
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu, Sichuan, Peoples R China;
Recommended Citation
GB/T 7714
Yuan, Wen,Pan, Yang,Zhang, Xiaoke,et al. Direct and highly stereoselective synthesis of quinolizidine iminosugars promoted by L-proline-Et3N[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2019,16(47):9230-9236.
APA Yuan, Wen.,Pan, Yang.,Zhang, Xiaoke.,Liang, Peng.,Zhang, Jichao.,...&Shao, Huawu.(2019).Direct and highly stereoselective synthesis of quinolizidine iminosugars promoted by L-proline-Et3N.ORGANIC & BIOMOLECULAR CHEMISTRY,16(47),9230-9236.
MLA Yuan, Wen,et al."Direct and highly stereoselective synthesis of quinolizidine iminosugars promoted by L-proline-Et3N".ORGANIC & BIOMOLECULAR CHEMISTRY 16.47(2019):9230-9236.

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来源:成都生物研究所

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