Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva
文献类型：期刊论文
| 作者 | Pu, De-Bing2,3; Du, Bao-Wen1; Chen, Wen2; Gao, Jun-Bo3; Hu, Kun3; Shi,Nan1; Li, Yi-Ming2; Zhang, Xing-Jie2; Zhang, Rui-Han2; Li, Xiao-Nian3 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019-10-05 |
| 卷号 | 20期号:19页码:6314-6317 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.8b02845 |
| 产权排序 | 2 |
| 文献子类 | Article |
| 英文摘要 | Premnafulvol A (1), a unique diterpenoid featuring a 6/5/7/3-fused tetracyclic carbon skeleton, with three biosynthetically related analogues, premnafulvols B-D (2-4), were isolated from the aerial parts of Premna fulva. Structures of 1-4 were established by a combination of extensive spectroscopic analyses, quantum chemical calculations, and X-ray crystallography. Plausible biosynthetic pathways of 1-4 were proposed. Interestingly, 2 and 3 exhibited opposite effects on estrogen biosynthesis in human ovarian granulosa-like KGN cells by modulating the expression of aromatase. |
| 学科主题 | Organic Chemistry/polymer Science |
| URL标识 | 查看原文 |
| WOS关键词 | AROMATASE INHIBITORS ; THERAPY ; ROOTS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000447118200072 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://210.75.237.14/handle/351003/30135]  |
| 专题 | 国家天然药物工程技术研究中心_天然产物研究 |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China; 2.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China; 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pu, De-Bing,Du, Bao-Wen,Chen, Wen,et al. Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva[J]. ORGANIC LETTERS,2019,20(19):6314-6317. |
| APA | Pu, De-Bing.,Du, Bao-Wen.,Chen, Wen.,Gao, Jun-Bo.,Hu, Kun.,...&Xiao, Wei-Lie.(2019).Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva.ORGANIC LETTERS,20(19),6314-6317. |
| MLA | Pu, De-Bing,et al."Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva".ORGANIC LETTERS 20.19(2019):6314-6317. |
入库方式： OAI收割
来源：成都生物研究所
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