A Multi-Class, Multi-Residue Method for Detection of Veterinary Drugs in Multiple Meat Using a Pass-Through Cleanup SPE Technique and UPLC-MS/MS Analysis
文献类型：期刊论文
| 作者 | Zhang, Yanxia2; Xue, Xia2; Su, Shufang2; Guo, Zhimou1; Wang, Jun2; Ding, Lisheng3; Liu, Yanming2; Zhu, Jianhua2 |
| 刊名 | FOOD ANALYTICAL METHODS
 |
| 出版日期 | 2018-10-01 |
| 卷号 | 11期号:10页码:2865-2884 |
| 关键词 | Veterinary drugs Multi-residue analysis Meat Pass-through cleanup UPLC-MS/MS |
| ISSN号 | 1936-9751 |
| DOI | 10.1007/s12161-018-1244-8 |
| 产权排序 | 3 |
| 文献子类 | Article |
| 英文摘要 | A quantitative method using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) was developed for the determination of 60 compounds, belonging to a variety of veterinary drug (VD) classes, in meat. The included analytes belong to the following VD classes: beta-agonists, sulfanilamides, quinolones, macrolides, tetracyclines, beta-lactams, nitroimidazoles, glucocorticoids, sex hormones, chloromycetins, sedatives, and olaquindox metabolite. The effective PRiME pass-through cleanup procedure was used to ensure high extraction efficiency and good sample cleanup after a simple liquid extraction of the meat samples with acetonitrile/water. The developed method was validated successfully. Mean recoveries for all analytes ranged from 80 to 116%, with the relative standard deviations (RSDs) <= 7.8%. Limits of quantification were in the range 0.05-3.0 mu g kg(-1) and limits of detection were in the range 0.1-10 mu g kg(-1). The matrix effect was evaluated for the different meat matrices and was found to be markedly different in different matrices. The validated method was used in a pilot study to analyze real samples of pork, beef, mutton, chicken, and pork liver, lambs' liver, and chicken liver. Trace amounts of beta-agonists, oxytetracycline, quinolones, chloromycetin sulfadimidine, and 3-methyl-quinoxaline-2-carboxylicacid were detected in these samples. In conclusion, this workflow can provide a simpler and more cost-effective alternative to conventional analytical methods and is compatible with processing large sample numbers in a short time period. |
| 学科主题 | Food Science/nutrition |
| URL标识 | 查看原文 |
| WOS关键词 | TANDEM MASS-SPECTROMETRY ; SOLID-PHASE EXTRACTION ; LIQUID-CHROMATOGRAPHY ; UHPLC-MS/MS ; MULTIRESIDUE DETERMINATION ; MILK ; ANTIBIOTICS ; VALIDATION ; MUSCLE ; CHLORAMPHENICOL |
| WOS研究方向 | Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000443476100022 |
| 出版者 | SPRINGER |
| 源URL | [http://210.75.237.14/handle/351003/30140]  |
| 专题 | 国家天然药物工程技术研究中心_天然产物研究 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian, Peoples R China; 2.Shandong Inst Food & Drug Control, 2749 Xinluo Rd, Jinan 250101, Shandong, Peoples R China; 3.Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yanxia,Xue, Xia,Su, Shufang,et al. A Multi-Class, Multi-Residue Method for Detection of Veterinary Drugs in Multiple Meat Using a Pass-Through Cleanup SPE Technique and UPLC-MS/MS Analysis[J]. FOOD ANALYTICAL METHODS,2018,11(10):2865-2884. |
| APA | Zhang, Yanxia.,Xue, Xia.,Su, Shufang.,Guo, Zhimou.,Wang, Jun.,...&Zhu, Jianhua.(2018).A Multi-Class, Multi-Residue Method for Detection of Veterinary Drugs in Multiple Meat Using a Pass-Through Cleanup SPE Technique and UPLC-MS/MS Analysis.FOOD ANALYTICAL METHODS,11(10),2865-2884. |
| MLA | Zhang, Yanxia,et al."A Multi-Class, Multi-Residue Method for Detection of Veterinary Drugs in Multiple Meat Using a Pass-Through Cleanup SPE Technique and UPLC-MS/MS Analysis".FOOD ANALYTICAL METHODS 11.10(2018):2865-2884. |
入库方式： OAI收割
来源：成都生物研究所
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