Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-kappa B signaling pathways
文献类型：期刊论文
| 作者 | Jouda, Jean-Bosco2; Njoya, Emmanuel Mfotie1,5; Mbazoa, Celine Djama2; Zhou, ZongYuan1; Lannang, Alain Meli3,4; Wandji, Jean2; Shiono, Yoshihito3; Wang, Fei1 |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2018-10-01 |
| 卷号 | 80期号:2018页码:2016-222 |
| 关键词 | Pycnoporus sanguineus Lambertellin Nitric oxide Anti-inflammatory Cytokines MAPKs NE-kappa B |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2018.06.021 |
| 产权排序 | 2 |
| 文献子类 | Article |
| 英文摘要 | Lambertellin (1) and ergosta-5,7,22-trien-3-ol (2) were isolated from the solid rice fermentation of the plant pathogenic fungus Pycnoporus sanguineus MUCL 51321. Their structures were elucidated using comprehensive spectroscopic methods. The isolated compounds were tested on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Lambertellin (1) exhibited promising inhibitory activity against nitric oxide (NO) production with IC50 value of 3.19 mu M, and it significantly inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2). Lambertellin (1) also decreased the expression of pro-inflammatory cytokines IL-6 and IL-1 beta. The study of the mechanistic pathways revealed that lambertellin (1) exerts its anti-inflammatory effect in LPS-stimulated RAW 264.7 macrophage cells by modulating the activation of the mitogen activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappa B) signaling pathways. Therefore, lambertellin (1) could be a promising lead compound for the development of new anti-inflammatory drugs. |
| 学科主题 | Chemistry ; Analysis |
| URL标识 | 查看原文 |
| WOS关键词 | INFLAMMATORY DISORDERS ; STRUCTURE ELUCIDATION ; ALOE-EMODIN ; INHIBITION ; MACROPHAGES ; ACTIVATION ; DISEASES ; CANCER ; CELLS ; INTERLEUKIN-1-BETA |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000441537800025 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://210.75.237.14/handle/351003/30149]  |
| 专题 | 国家天然药物工程技术研究中心_天然产物研究 国家天然药物工程技术研究中心_天然药物与临床转化重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu, Sichuan, Peoples R China; 2.Univ Yaounde I, Fac Sci, Dept Organ Chem, POB 812, Yaounde, Cameroon; 3.Yamagata Univ, Fac Agr, Dept Food Life & Environm Sci, Tsuruoka, Yamagata, Japan 4.Univ Maroua, Higher Teachers Training Coll, Dept Chem, POB 55, Maroua, Cameroon; 5.Univ Yaounde I, Fac Sci, Dept Biochem, POB 812, Yaounde, Cameroon; |
| 推荐引用方式 GB/T 7714 | Jouda, Jean-Bosco,Njoya, Emmanuel Mfotie,Mbazoa, Celine Djama,et al. Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-kappa B signaling pathways[J]. BIOORGANIC CHEMISTRY,2018,80(2018):2016-222. |
| APA | Jouda, Jean-Bosco.,Njoya, Emmanuel Mfotie.,Mbazoa, Celine Djama.,Zhou, ZongYuan.,Lannang, Alain Meli.,...&Wang, Fei.(2018).Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-kappa B signaling pathways.BIOORGANIC CHEMISTRY,80(2018),2016-222. |
| MLA | Jouda, Jean-Bosco,et al."Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-kappa B signaling pathways".BIOORGANIC CHEMISTRY 80.2018(2018):2016-222. |
入库方式： OAI收割
来源：成都生物研究所
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