(-)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo
文献类型：期刊论文
| 作者 | Chen, Yuwen; Li, Wenhua; Zeng, Zhongqiu; Tang, Yaxiong |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2019-06-11 |
| 卷号 | 8页码:8807 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-018-27036-6 |
| 产权排序 | 1 |
| 文献子类 | Article |
| 英文摘要 | With limited success achieved in bladder cancer patient management, novel agents are in urgent need for the purpose of therapy and prevention. As a sesquiterpenoid dimmer isolated from Gochnatia pomculat, (-)-gochnatiolide B has been bio-mimetically synthesized in multiple steps with a poor yield, which heavily limited the further research and clinical application. Herein, (-)-gochnatiolide B was synthesized beginning with dehydrocostuslactone in four steps with a total yield of 26%. MTT assays showed that (-)-gochnatiolide B inhibited the growth of vast majority of human cancer cells especially bladder cancer cells. Mechanistically, (-)-gochnatiolide B induced the increased expression of pro-apoptotic proteins and the decreased expression of anti-apoptosis proteins and further resulted in apoptosis of T24 cells. (-)-Gochnatiolide B induced G1 arrest which associated with SKP2 downregulation, leading to p27/Kip1 accumulation and downregulation of cyclin D1 in T24 cells. Furthermore, in vivo studies showed that (-)-gochnatiolide B remarkably inhibited tumor growth by 81% compared with vehicle control. Taken together, (-)-gochnatiolide B exhibits inhibitory activity against bladder cancer cells both in vitro and in vivo by inducing apoptosis, which suggests that (-)-gochnatiolide B could be an important candidate compound for prevention and treatment of bladder cancer. |
| 学科主题 | Multidisciplinary |
| URL标识 | 查看原文 |
| WOS关键词 | CYCLIN D1 ; BIOMIMETIC SYNTHESES ; FLAVOKAWAIN B ; TUMOR-GROWTH ; BIM ; APOPTOSIS ; AINSLIADIMER ; EXPRESSION ; PROTEOMICS ; MECHANISM |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000434776600013 |
| 源URL | [http://210.75.237.14/handle/351003/30229]  |
| 专题 | 国家天然药物工程技术研究中心_天然产物研究 |
| 作者单位 | Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yuwen,Li, Wenhua,Zeng, Zhongqiu,et al. (-)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo[J]. SCIENTIFIC REPORTS,2019,8:8807. |
| APA | Chen, Yuwen,Li, Wenhua,Zeng, Zhongqiu,&Tang, Yaxiong.(2019).(-)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo.SCIENTIFIC REPORTS,8,8807. |
| MLA | Chen, Yuwen,et al."(-)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo".SCIENTIFIC REPORTS 8(2019):8807. |
入库方式： OAI收割
来源：成都生物研究所
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