Tmem30a Plays Critical Roles in Ensuring the Survival of Hematopoietic Cells and Leukemia Cells in Mice
文献类型：期刊论文
| 作者 | Li, Ning1,5; Yang, Yeming4; Liang, Cailing1,5; Qiu, Qiang1,5; Pan, Cong1,5; Li, Mengyuan1,5; Yang, Shengyong1; Chen, Lijuan1; Zhu, Xianjun2,3,4; Hu, Yiguo1,5 |
| 刊名 | AMERICAN JOURNAL OF PATHOLOGY
 |
| 出版日期 | 2018-06-01 |
| 卷号 | 188期号:6页码:1457-1468 |
| ISSN号 | 0002-9440 |
| DOI | 10.1016/j.ajpath.2018.02.015 |
| 产权排序 | 5 |
| 文献子类 | Article |
| 英文摘要 | The fundamental structure of eukaryotic cell plasma membrane is the phospholipid bilayer, which contains four major phospholipids. These phospholipids are asymmetrically distributed between the outer and inner leaflets. P4-ATPase flippase complexes play essential roles in ensuring this asymmetry. We found that conditional deletion of Tmem30a, the beta subunit of P4-ATPase flippase complex, caused pancytopenia in mice. Tmem30a deficiency resulted in depletion of lineage-committed blood cells in the peripheral blood, spleen, and bone marrow. Ablation of Tmem30a also caused the depletion of hematopoietic stem cells (HSCs). HSC RNA sequencing results revealed that multiple biological processes and signal pathways were involved in the event, including mammalian target of rapamycin signaling, genes for HSC sternness, and genes responding to interferons. Our results also revealed that targeting Tmem30a signaling had therapeutic utility in BCR/ABL1-induced chronic myeloid leukemia. |
| 学科主题 | Research ; Laboratory Medicine ; Medical Technology |
| URL标识 | 查看原文 |
| WOS关键词 | P-TYPE ATPASE ; HUMAN INTERACTOME ; ATP8A2 GENE ; PROTEIN ; PHOSPHATIDYLSERINE ; ATP11C ; EXPRESSION ; MOUSE ; TRANSLOCASE ; DISRUPTION |
| WOS研究方向 | Pathology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE INC |
| WOS记录号 | WOS:000433524800012 |
| 源URL | [http://210.75.237.14/handle/351003/30240]  |
| 专题 | 国家天然药物工程技术研究中心_天然产物研究 天然产物研究中心_中国科学院四川转化医学研究院 |
| 作者单位 | 1.the Department of Thyroid Surgery,State Key Laboratory of Biotherapy & Collaborative Innovation Center for Biotherapy; 2.the Chengdu Institute of Biology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan, China 3.the Department of Laboratory Medicine,Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu; 4.Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China, Chengdu, Sichuan; 5.West China Hospital,Sichuan University, Chengdu, Sichuan; the Sichuan Provincial Key Laboratory for Human Disease Gene Study; |
| 推荐引用方式 GB/T 7714 | Li, Ning,Yang, Yeming,Liang, Cailing,et al. Tmem30a Plays Critical Roles in Ensuring the Survival of Hematopoietic Cells and Leukemia Cells in Mice[J]. AMERICAN JOURNAL OF PATHOLOGY,2018,188(6):1457-1468. |
| APA | Li, Ning.,Yang, Yeming.,Liang, Cailing.,Qiu, Qiang.,Pan, Cong.,...&Hu, Yiguo.(2018).Tmem30a Plays Critical Roles in Ensuring the Survival of Hematopoietic Cells and Leukemia Cells in Mice.AMERICAN JOURNAL OF PATHOLOGY,188(6),1457-1468. |
| MLA | Li, Ning,et al."Tmem30a Plays Critical Roles in Ensuring the Survival of Hematopoietic Cells and Leukemia Cells in Mice".AMERICAN JOURNAL OF PATHOLOGY 188.6(2018):1457-1468. |
入库方式： OAI收割
来源：成都生物研究所
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