Metal coordination protocol for the synthesis of-2,3-dehydrosilybin and 19-O-demethy1-2,3-dehydrosilybin from silybin and their antitumor activities
文献类型：期刊论文
| 作者 | Wen, Yong-ju1,3,4; Zhou, Zong-yuan1,3; Zhang, Guo-lin1; Lu, Xiao-xia1,2 |
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2019-04-25 |
| 卷号 | 59期号:17页码:1666-1669 |
| 关键词 | Silybin 2,3-Dehydrosilybin 19-O-Demethy1-2,3-dehydrosilybin Synthesis Metal chelating Antitumor |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2018.03.052 |
| 产权排序 | 1 |
| 文献子类 | Article |
| 英文摘要 | An efficient and practical method to access bioactive 2,3-dehydrosilybin and 19-O-demethy1-2,3-dehydrosilybin using naturally abundant flavonolignan silybin in the presence of metal salt as a chelating agent is described. The procedure presented here has several advantages including one-pot, synthetic ease, and products in high yields with no side reactions, and large-scale feasibility. The dehydrogenation and demethylation proceed smoothly via a one-pot process using the AlCl3/Pyridine system and 12 as the additive. Furthermore, 2,3-dehydrosilybin and 19-O-demethy1-2,3-dehydrosilybin can inhibit the expression of intracellular mature miRNA-21 with IC50 values of 4.46 mu M and 8.25 mu M, respectively, and show moderate anticancer activities against HeLa cell lines. (C) 2018 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry ; Analysis |
| URL标识 | 查看原文 |
| WOS关键词 | ANTIOXIDANT ACTION ; 2,3-DEHYDROSILYBIN ; FLAVONOLIGNANS ; DERIVATIVES ; CLEAVAGE ; DEMETHYLATION ; MECHANISM ; ETHERS ; ESTER ; DNA |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000430524700013 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://210.75.237.14/handle/351003/30271]  |
| 专题 | 国家天然药物工程技术研究中心_天然产物研究 |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China; 2.Hainan Normal Univ, Minist Educ, Key Lab Trop Med Plant Chem, Haikou 571127, Hainan, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Yichun Univ, Chem & Biol Bioengn Coll, Yichun 336000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Yong-ju,Zhou, Zong-yuan,Zhang, Guo-lin,et al. Metal coordination protocol for the synthesis of-2,3-dehydrosilybin and 19-O-demethy1-2,3-dehydrosilybin from silybin and their antitumor activities[J]. TETRAHEDRON LETTERS,2019,59(17):1666-1669. |
| APA | Wen, Yong-ju,Zhou, Zong-yuan,Zhang, Guo-lin,&Lu, Xiao-xia.(2019).Metal coordination protocol for the synthesis of-2,3-dehydrosilybin and 19-O-demethy1-2,3-dehydrosilybin from silybin and their antitumor activities.TETRAHEDRON LETTERS,59(17),1666-1669. |
| MLA | Wen, Yong-ju,et al."Metal coordination protocol for the synthesis of-2,3-dehydrosilybin and 19-O-demethy1-2,3-dehydrosilybin from silybin and their antitumor activities".TETRAHEDRON LETTERS 59.17(2019):1666-1669. |
入库方式： OAI收割
来源：成都生物研究所
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