D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria
文献类型：期刊论文
| 作者 | Yang, Xinglong1,2,3,4; Dang, Yan5; Lou, Jinli5; Shao, Huawu3; Jiang, Xingyu2,4 |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:5页码:1449-1457 |
| 关键词 | gold nanoparticles D-amino acid bacteria spontaneous bacterial peritonitis colorimetric biosensor |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.22540 |
| 产权排序 | 2 |
| 文献子类 | Article |
| 英文摘要 | Rationale: Rapid and facile detection of pathogenic bacteria is challenging due to the requirement of large-scale instruments and equipment in conventional methods. We utilize D-amino acid as molecules to selectively target bacteria because bacteria can incorporate DADA in its cell wall while mammalian cells or fungi cannot. Methods: We show a broad-spectrum bacterial detection system based on D-amino acid-capped gold nanoparticles (AuNPs). AuNPs serve as the signal output that we can monitor without relying on any complex instruments. Results: In the presence of bacteria, the AuNPs aggregate and the color of AuNPs changes from red to blue. This convenient color change can distinguish between Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA). This system can be applied for detection of ascites samples from patients. Conclusion: These D-amino acid-modified AuNPs serve as a promising platform for rapid visual identification of pathogens in the clinic. |
| URL标识 | 查看原文 |
| WOS关键词 | D-AMINO ACIDS ; MULTIDRUG-RESISTANT BACTERIA ; CELL-WALL ; PEPTIDOGLYCAN BIOSYNTHESIS ; SILVER NANOPARTICLES ; PHOTOTHERMAL THERAPY ; MEDIATED GROWTH ; SMALL MOLECULES ; NAKED EYE ; CANCER |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000424515900020 |
| 出版者 | IVYSPRING INT PUBL |
| 源URL | [http://210.75.237.14/handle/351003/30371]  |
| 专题 | 国家天然药物工程技术研究中心_天然产物研究 |
| 作者单位 | 1.Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Shandong, Peoples R China 2.ZhongGuanCun BeiYiTiao, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing Engn Res Ctr BioNanotechnol, Natl Ctr NanoSci & Technol,CAS Ctr Excellence Nan, Beijing 100190, Peoples R China; 3.Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Sichuan, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 5.Capital Med Univ, Beijing Youan Hosp, Dept Clin Lab, 8 Youan Men Wai Xi TouTiao, Beijing 100069, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Xinglong,Dang, Yan,Lou, Jinli,et al. D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria[J]. THERANOSTICS,2018,8(5):1449-1457. |
| APA | Yang, Xinglong,Dang, Yan,Lou, Jinli,Shao, Huawu,&Jiang, Xingyu.(2018).D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria.THERANOSTICS,8(5),1449-1457. |
| MLA | Yang, Xinglong,et al."D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria".THERANOSTICS 8.5(2018):1449-1457. |
入库方式： OAI收割
来源：成都生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。