Synthesis and inhibitory effect of 10-chlorocanthin-6-one on ovarian cancer HO8910PM cells
文献类型：期刊论文
| 作者 | Li, Wenhua1; Chen, Yuwen1,2; Sheng, Yuwen1; Xie, Zeyu1; Tang, Yaxiong1 |
| 刊名 | BIOTECHNOLOGY LETTERS
 |
| 出版日期 | 2018 |
| 卷号 | 40期号:1页码:23-30 |
| 关键词 | Bim Cell apoptosis 10-Chlorocanthin-6-one Cytotoxicity Ovarian cancer cell line |
| ISSN号 | 0141-5492 |
| DOI | 10.1007/s10529-017-2438-7 |
| 产权排序 | 1 |
| 文献子类 | Article |
| 英文摘要 | To synthesize and determine the antitumor activity of 10-chlorocanthin-6-one in ovarian cancer HO8910PM cells. Among the synthesized canthin-6-one analogs, 10-chlorocanthin-6-one was the most cytotoxic (IC50 = 4.9 mu M), as demonstrated by a dose-dependent cytotoxicity assay. Moreover, 10-chlorocanthin-6-one induced apoptosis through the activation of poly(ADP-ribose) polymerase and caspase-3 cleavage, upregulation of Bcl-2, and downregulation of Bim, x-linked inhibitor of apoptosis protein (XIAP), and survivin in HO8910PM cells. Furthermore, Bim RNA, upregulated in a concentration-dependent manner, and knockdown of Bim via short-hairpin RNAs attenuated the inhibitory effects of 10-chlorocanthin-6-one on HO8910PM cell growth. 10-Chlorocanthin-6-one inhibits cell proliferation and induces apoptosis in H08910PM cells. The underlying molecular mechanisms of 10-chlorocanthin-6-one include activation of the Bim-mediated mitochondrial apoptotic pathway via upregulation of Bim and downregulation of Bcl-2, XIAP, and survivin. These data suggest that Bim is a potential target of 10-chlorocanthin-6-one, further demonstrating its potential use in the prevention and treatment of ovarian cancer. |
| 学科主题 | Biotechnology ; Applied Microbiology |
| URL标识 | 查看原文 |
| WOS关键词 | STATISTICS ; SITE |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000424228200003 |
| 出版者 | SPRINGER |
| 源URL | [http://210.75.237.14/handle/351003/30388]  |
| 专题 | 国家天然药物工程技术研究中心_天然产物研究 |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Biol, 9 Sect 4,Renmin Nan Rd, Chengdu 610041, Sichuan, Peoples R China; 2.Sichuan Univ, Sch Life Sci & Engn, Chengdu, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Wenhua,Chen, Yuwen,Sheng, Yuwen,et al. Synthesis and inhibitory effect of 10-chlorocanthin-6-one on ovarian cancer HO8910PM cells[J]. BIOTECHNOLOGY LETTERS,2018,40(1):23-30. |
| APA | Li, Wenhua,Chen, Yuwen,Sheng, Yuwen,Xie, Zeyu,&Tang, Yaxiong.(2018).Synthesis and inhibitory effect of 10-chlorocanthin-6-one on ovarian cancer HO8910PM cells.BIOTECHNOLOGY LETTERS,40(1),23-30. |
| MLA | Li, Wenhua,et al."Synthesis and inhibitory effect of 10-chlorocanthin-6-one on ovarian cancer HO8910PM cells".BIOTECHNOLOGY LETTERS 40.1(2018):23-30. |
入库方式： OAI收割
来源：成都生物研究所
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