Antiproliferative Sesquiterpenoids from Ligularia rumicifolia with Diverse Skeletons
文献类型：期刊论文
| 作者 | Ye, Ye4,5; Dawa, Drolma3,4; Liu, Guang-Hui4,5; Zhao, Min5; Tseden, Dorje3,4; Gu, Yu-Cheng2; Ding, Li-Sheng5; Cao, Zhi-Xing1; Zhou, Yan5 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2018-09-01 |
| 卷号 | 81期号:9页码:1992-2003 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.8b00197 |
| 产权排序 | 1 |
| 文献子类 | Article |
| 英文摘要 | Twenty-two new sesquiterpenoids with four skeletal types and 15 known analogues were isolated from the whole plants of Ligularia rumicifolia. The structures of the isolates were elucidated based on comprehensive spectroscopic data analysis. Compound 1 is a C-14 nor-sesquiterpenoid featuring a 6/6/6 tricyclic skeleton with a 9,13-ether bridge. The absolute configuration of 2 was established through single-crystal X-ray diffraction data. Compounds 13-16 exhibited in vitro antiproliferative activity against the four human tumor cell lines A-549, HGC-27, HeLa, and MV4-11. Specifically, compounds 13 and 16 showed antiproliferative activity against the MV4-11 cell line with IC50 values of 0.5 +/- 0.2 and 1.1 +/- 0.5 mu M, respectively. |
| 学科主题 | Agricultural Chemistry |
| URL标识 | 查看原文 |
| WOS关键词 | EREMOPHILANE-TYPE SESQUITERPENES ; BISABOLANE SESQUITERPENES ; NITRIC-OXIDE ; TUSSILAGO-FARFARA ; A-E ; ROOTS ; DERIVATIVES ; TERPENOIDS ; RHIZOMES ; CHINA |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000446276600010 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://210.75.237.14/handle/351003/30167]  |
| 专题 | 公共实验与分析中心 |
| 作者单位 | 1.Chengdu Univ Tradit Chinese Med, Pharm Coll, Chengdu 611137, Sichuan, Peoples R China 2.Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England 3.Tibet Autonomous Reg Inst Food & Drug Control, Lhasa 850000, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Ye,Dawa, Drolma,Liu, Guang-Hui,et al. Antiproliferative Sesquiterpenoids from Ligularia rumicifolia with Diverse Skeletons[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(9):1992-2003. |
| APA | Ye, Ye.,Dawa, Drolma.,Liu, Guang-Hui.,Zhao, Min.,Tseden, Dorje.,...&Zhou, Yan.(2018).Antiproliferative Sesquiterpenoids from Ligularia rumicifolia with Diverse Skeletons.JOURNAL OF NATURAL PRODUCTS,81(9),1992-2003. |
| MLA | Ye, Ye,et al."Antiproliferative Sesquiterpenoids from Ligularia rumicifolia with Diverse Skeletons".JOURNAL OF NATURAL PRODUCTS 81.9(2018):1992-2003. |
入库方式： OAI收割
来源：成都生物研究所
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