Gas-phase intramolecular hydroxyl-amino exchange of protonated arginine and verified by the synthetic intermediate compound
文献类型：期刊论文
| 作者 | Cai, Tian2; Zhou, Jing1; Jiang, Yan2; Xie, Kexin2; Fang, Dongmei2; Qi, Huayi2; Wu, Zhijun2 |
| 刊名 | JOURNAL OF MASS SPECTROMETRY
 |
| 出版日期 | 2018-08-01 |
| 卷号 | 53期号:8页码:700-704 |
| 关键词 | DFT calculation ion-neutral complex LC-MS m/z 130 ion protonated arginine |
| ISSN号 | 1076-5174 |
| DOI | 10.1002/jms.4208 |
| 产权排序 | 1 |
| 文献子类 | Article |
| 英文摘要 | A new fragmentation process was proposed to interpret the characteristic product ion at m/z 130 of protonated arginine. The a-amino group was dissociated from protonated arginine and then combined with the (M + H-NH3) fragment to form an ion-neutral complex which further generated a hydroxyl-amino exchange intermediate compound through an ion-molecule reaction. This intermediate compound was synthesized from argininamide through a diazo reaction, and then the reaction mixture was analyzed using liquid chromatography combined with mass spectrometry (LC-MS). The collision-induced dissociation experiments under the same conditions revealed that this intermediate compound produced the characteristic product ion at m/z 130 as well as protonated arginine, and in addition, density functional theory calculations were performed to confirm simultaneous loss of NH3 and CO from this intermediate to give the m/z 130 ion. |
| 学科主题 | Chemistry ; Analysis |
| URL标识 | 查看原文 |
| WOS关键词 | MOLECULAR-ORBITAL METHODS ; GAUSSIAN-TYPE BASIS ; MASS-SPECTROMETRY ; ORGANIC-MOLECULES ; ACIDS ; FRAGMENTATION ; IONIZATION ; METABOLISM ; MECHANISMS ; DIAGNOSIS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000441248100008 |
| 出版者 | WILEY |
| 源URL | [http://210.75.237.14/handle/351003/30193]  |
| 专题 | 公共实验与分析中心 |
| 作者单位 | 1.Chongqing Med Univ, Sch Pharm, Chongqing 400016, Peoples R China 2.Univ Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cai, Tian,Zhou, Jing,Jiang, Yan,et al. Gas-phase intramolecular hydroxyl-amino exchange of protonated arginine and verified by the synthetic intermediate compound[J]. JOURNAL OF MASS SPECTROMETRY,2018,53(8):700-704. |
| APA | Cai, Tian.,Zhou, Jing.,Jiang, Yan.,Xie, Kexin.,Fang, Dongmei.,...&Wu, Zhijun.(2018).Gas-phase intramolecular hydroxyl-amino exchange of protonated arginine and verified by the synthetic intermediate compound.JOURNAL OF MASS SPECTROMETRY,53(8),700-704. |
| MLA | Cai, Tian,et al."Gas-phase intramolecular hydroxyl-amino exchange of protonated arginine and verified by the synthetic intermediate compound".JOURNAL OF MASS SPECTROMETRY 53.8(2018):700-704. |
入库方式： OAI收割
来源：成都生物研究所
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