RECENT (2000-2015) DEVELOPMENTS IN THE ANALYSIS OF MINOR UNKNOWN NATURAL PRODUCTS BASED ON CHARACTERISTIC FRAGMENT INFORMATION USING LC-MS
文献类型：期刊论文
| 作者 | Cai, Tian1,3,4; Guo, Ze-Qin2,4; Xu, Xiao-Ying1; Wu, Zhi-Jun4 |
| 刊名 | MASS SPECTROMETRY REVIEWS
 |
| 出版日期 | 2018-03-01 |
| 卷号 | 37期号:2页码:202-216 |
| 关键词 | natural products LC-MS determination of molecular formula RDA McLafferty rearrangements internal residue loss ion-neutral complex |
| ISSN号 | 0277-7037 |
| DOI | 10.1002/mas.21514 |
| 产权排序 | 1 |
| 文献子类 | Review |
| 英文摘要 | Liquid chromatography-Mass Spectrometry (LC-MS) has been widely used in natural product analysis. Global detection and identification of nontargeted components are desirable in natural product research, for example, in quality control of Chinese herbal medicine. Nontargeted components analysis continues to expand to exciting life science application domains such as metabonomics. With this background, the present review summarizes recent developments in the analysis of minor unknown natural products using LC-MS and mainly focuses on the determination of the molecular formulae, selection of precursor ions, and characteristic fragmentation patterns of the known compounds. This review consists of three parts. Firstly, the methods used to determine unique molecular formula of unknown compounds such as accurate mass measurements, MSn spectra, or relative isotopic abundance information, are introduced. Secondly, the methods improving signal-to-noise ratio of MS/MS spectra by manual-MS/MS or workflow targeting-only signals were elucidated; pure precursor ions can be selected by changing the precursor ion isolated window. Lastly, characteristic fragmentation patterns such as Retro-Diels-Alder (RDA), McLafferty rearrangements, "internal residue loss," and so on, occurring in the molecular ions of natural products are summarized. Classical application of characteristic fragmentation patterns in identifying unknown compounds in extracts and relevant fragmentation mechanisms are presented (RDA reactions occurring readily in the molecular ions of flavanones or isoflavanones, McLafferty-type fragmentation reactions of some natural products such as epipolythiodioxopiperazines; fragmentation by "internal residue loss" possibly involving ion-neutral complex intermediates). (c) 2016 Wiley Periodicals, Inc. |
| 学科主题 | Spectroscopy ; Instrumentation ; Analytical Sciences |
| URL标识 | 查看原文 |
| WOS关键词 | TANDEM MASS-SPECTROMETRY ; OF-FLIGHT MASS ; COLLISION-INDUCED DISSOCIATION ; NEGATIVE ELECTROSPRAY-IONIZATION ; TRADITIONAL CHINESE MEDICINE ; INTERNAL RESIDUE LOSS ; QUADRUPOLE ION-TRAP ; ELEMENTAL COMPOSITION DETERMINATION ; SESQUITERPENE PYRIDINE ALKALOIDS ; ISOTOPIC ABUNDANCE MEASUREMENTS |
| WOS研究方向 | Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000424850200006 |
| 出版者 | WILEY |
| 源URL | [http://210.75.237.14/handle/351003/30323]  |
| 专题 | 公共实验与分析中心 |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Sichuan, Peoples R China; 2.Chongqing Univ, Coll Bioengn, Chongqing 400044, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China; 4.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cai, Tian,Guo, Ze-Qin,Xu, Xiao-Ying,et al. RECENT (2000-2015) DEVELOPMENTS IN THE ANALYSIS OF MINOR UNKNOWN NATURAL PRODUCTS BASED ON CHARACTERISTIC FRAGMENT INFORMATION USING LC-MS[J]. MASS SPECTROMETRY REVIEWS,2018,37(2):202-216. |
| APA | Cai, Tian,Guo, Ze-Qin,Xu, Xiao-Ying,&Wu, Zhi-Jun.(2018).RECENT (2000-2015) DEVELOPMENTS IN THE ANALYSIS OF MINOR UNKNOWN NATURAL PRODUCTS BASED ON CHARACTERISTIC FRAGMENT INFORMATION USING LC-MS.MASS SPECTROMETRY REVIEWS,37(2),202-216. |
| MLA | Cai, Tian,et al."RECENT (2000-2015) DEVELOPMENTS IN THE ANALYSIS OF MINOR UNKNOWN NATURAL PRODUCTS BASED ON CHARACTERISTIC FRAGMENT INFORMATION USING LC-MS".MASS SPECTROMETRY REVIEWS 37.2(2018):202-216. |
入库方式： OAI收割
来源：成都生物研究所
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