Diastereo- and Enantioselective Dearomative [3+2] Cycloaddition Reaction of 2-Nitrobenzofurans with 3-Isothiocyanato Oxindoles
文献类型：期刊论文
| 作者 | Zhao, Jian-Qiang1; Zhou, Xiao-Jian3,4; Zhou, Yan2; Xu, Xiao-Ying4; Zhang, Xiao-Mei4; Yuan, Wei-Cheng4 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019-02-16 |
| 卷号 | 20期号:4页码:909-912 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.7b03667 |
| 产权排序 | 3 |
| 文献子类 | Article |
| 英文摘要 | Enantioselective dearomative [3 + 2] cycloaddition reaction of 2-nitrobenzofurans with 3-isothiocyanato oxindoles was developed. The reaction employs a chiral bis(oxazoline)/Zn(OTf)(2) catalyst, allowing a practical, straightforward access to structurally diverse spirooxindoles containing a 2,3-dihydrobenzofuran motif and three contiguous stereo-centers with excellent diastereo- and enantioselectivities. The synthetic potentials of the method have been demonstrated by the scale-up experiment and transformations of the products. The preliminary mechanism was investigated with experimental observations, nonlinear effects studies, and MS experiments. |
| 学科主题 | Organic Chemistry ; Polymer Science |
| URL标识 | 查看原文 |
| WOS关键词 | CATALYTIC ASYMMETRIC DEAROMATIZATION ; MICHAEL/CYCLIZATION CASCADE REACTION ; GENERATED MAGNESIUM CATALYST ; FRIEDEL-CRAFTS ALKYLATION ; POLYCYCLIC SPIROOXINDOLES ; EFFICIENT SYNTHESIS ; FUSED HETEROCYCLES ; AZOMETHINE YLIDE ; INDOLES ; 3-NITROINDOLES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000426013600004 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://210.75.237.14/handle/351003/30330]  |
| 专题 | 公共实验与分析中心 |
| 作者单位 | 1.Chengdu Univ, Inst Adv Study, Chengdu 610106, Sichuan, Peoples R China; 2.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Chengdu Inst Organ Chem, Natl Engn Res Ctr Chiral Drugs, Chengdu 610041, Sichuan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Jian-Qiang,Zhou, Xiao-Jian,Zhou, Yan,et al. Diastereo- and Enantioselective Dearomative [3+2] Cycloaddition Reaction of 2-Nitrobenzofurans with 3-Isothiocyanato Oxindoles[J]. ORGANIC LETTERS,2019,20(4):909-912. |
| APA | Zhao, Jian-Qiang,Zhou, Xiao-Jian,Zhou, Yan,Xu, Xiao-Ying,Zhang, Xiao-Mei,&Yuan, Wei-Cheng.(2019).Diastereo- and Enantioselective Dearomative [3+2] Cycloaddition Reaction of 2-Nitrobenzofurans with 3-Isothiocyanato Oxindoles.ORGANIC LETTERS,20(4),909-912. |
| MLA | Zhao, Jian-Qiang,et al."Diastereo- and Enantioselective Dearomative [3+2] Cycloaddition Reaction of 2-Nitrobenzofurans with 3-Isothiocyanato Oxindoles".ORGANIC LETTERS 20.4(2019):909-912. |
入库方式： OAI收割
来源：成都生物研究所
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