Novel Disinfection Byproducts Formed from the Pharmaceutical Gemfibrozil Are Bioaccumulative and Elicit Increased Toxicity Relative to the Parent Compound in Marine Polychaetes (Neanthes arenaceodentata)
文献类型：期刊论文
| 作者 | Andrzejczyk, Nicolette E.2; Greer, Justin B.2; Nelson, Eric4; Zhang, Junqian1; Rimoldi, John M.3; Gadepalli, Rama S., V3; Edwards, Isaiah3; Schlenk, Daniel2 |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2020-09-15 |
| 卷号 | 54期号:18页码:11127-11136 |
| ISSN号 | 0013-936X |
| DOI | 10.1021/acs.est.0c01080 |
| 通讯作者 | Andrzejczyk, Nicolette E.(nandr009@ucr.edu) |
| 英文摘要 | Formation of halogenated disinfection byproducts (DBPs) from pharmaceutically active compounds has been observed in water supply systems following wastewater chlorination. Although research has been limited thus far, several studies have shown that halogenated DBPs may elicit increased toxicity compared to their parent compounds. For example, the lipid regulator gemfibrozil has been shown to form chlorogemfibrozil (Cl-gemfibrozil) and bromogemfibrozil (Br-gemfibrozil) following chlorination, which are more potent antiandrogens in male Japanese medaka (Oryzias latipes) compared to their parent compounds. In the present study, we aimed to characterize the bioaccumulative ability of halogenated gemfibrozil DBPs in marine polychaetes via chronic sediment exposures and, consequently, to assess the chronic and acute toxicity of halogenated gemfibrozil DBPs through sediment (in vivo) and aqueous (in vivo and in silico) toxicity evaluations. Following 28 day sediment exposures, Cl-gemfibrozil and Br-gemfibrozil bioaccumulated within Neanthes arenaceodentata, with both compounds reducing survival and growth. The biota-sediment accumulation factors determined for Cl-gemfibrozil and Br-gemfibrozil were 2.59 and 6.86, respectively. Furthermore, aqueous 96 h toxicity tests with N. arenaceodentata indicated that gemfibrozil DBPs elicited increased toxicity compared to the parent compound. While gemfibrozil had an acute LC50 value of 469.85 +/- 0.096 mg/L, Cl-gemfibrozil and Br-gemfibrozil had LC50 values of 12.34 +/- 0.085 and 9.54 +/- 0.086 mg/L, respectively. Although acute toxicity is relatively low, our results indicate that halogenated gemfibrozil DBPs are bioaccumulative and may elicit effects in apex food web organisms prone to accumulation following lifelong exposures. |
| WOS关键词 | PERSONAL CARE PRODUCTS ; DRINKING-WATER ; AQUEOUS CHLORINATION ; SIZE DISTRIBUTION ; TRANSFORMATION ; IDENTIFICATION ; GENOTOXICITY ; EFFLUENT ; CHEMICALS ; BIOASSAY |
| 资助项目 | National Institute of General Medical Sciences of the National Institutes of Health[P30GM122733] |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:000572834700015 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health ; National Institute of General Medical Sciences of the National Institutes of Health |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/38890]  |
| 专题 | 水生生物研究所_水生生物多样性与资源保护研究中心_期刊论文 |
| 通讯作者 | Andrzejczyk, Nicolette E. |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 2.Univ Calif Riverside, Dept Environm Sci, Riverside, CA 92521 USA 3.Univ Mississippi, Sch Pharm, Dept Biomol Sci, University, MS 38677 USA 4.Sanitat Dist Los Angeles Cty, San Jose Creek Water Qual Lab, Whittier, CA 90601 USA |
| 推荐引用方式 GB/T 7714 | Andrzejczyk, Nicolette E.,Greer, Justin B.,Nelson, Eric,et al. Novel Disinfection Byproducts Formed from the Pharmaceutical Gemfibrozil Are Bioaccumulative and Elicit Increased Toxicity Relative to the Parent Compound in Marine Polychaetes (Neanthes arenaceodentata)[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2020,54(18):11127-11136. |
| APA | Andrzejczyk, Nicolette E..,Greer, Justin B..,Nelson, Eric.,Zhang, Junqian.,Rimoldi, John M..,...&Schlenk, Daniel.(2020).Novel Disinfection Byproducts Formed from the Pharmaceutical Gemfibrozil Are Bioaccumulative and Elicit Increased Toxicity Relative to the Parent Compound in Marine Polychaetes (Neanthes arenaceodentata).ENVIRONMENTAL SCIENCE & TECHNOLOGY,54(18),11127-11136. |
| MLA | Andrzejczyk, Nicolette E.,et al."Novel Disinfection Byproducts Formed from the Pharmaceutical Gemfibrozil Are Bioaccumulative and Elicit Increased Toxicity Relative to the Parent Compound in Marine Polychaetes (Neanthes arenaceodentata)".ENVIRONMENTAL SCIENCE & TECHNOLOGY 54.18(2020):11127-11136. |
入库方式： OAI收割
来源：水生生物研究所
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