Visual system: An understudied target of aquatic toxicology
文献类型：期刊论文
| 作者 | Chen, Lianguo |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2020-08-01 |
| 卷号 | 225页码:12 |
| ISSN号 | 0166-445X |
| 关键词 | Visual system Aquatic toxicology Visual toxicity Toxic mechanism Thyroid Retinoids |
| DOI | 10.1016/j.aquatox.2020.105542 |
| 通讯作者 | Chen, Lianguo(lchenam@ihb.ac.cn) |
| 英文摘要 | Visual system is increasingly recognized as a sensitive target of xenobiotics in aquatic ecosystems. Various environmental pollutants of distinct physicochemical properties are able to impair the retinal development and function of teleost fishes, including dioxin-like pollutants, flame retardants, pesticides, perfluoroalkyl acids, retinoic acids and metals. Considering the availability of developmental and functional database, zebrafish has been the most frequently used as the teleost model to study aquatic visual toxicology. A diversity of visual deficits has been displayed for fishes across multiple levels of biological organizations (e.g., molecule, cell, histology, physiology and behavior). Covering sensitive developmental windows of eyes during early embryogenesis, acute or chronic exposure to xenobiotics can disturb the expressions of visual gene and protein markers, which affect the retinal neurogenesis and induce degeneration of neurons. Morphological structures and physiological responses of retina and optic rectum are then disorganized, eventually compromising the performance of visually-mediated behaviors and recruitment of individuals. Environmental pollutants can cross the blood-retina barrier and accumulate in eyes, which might impact visual system directly. In addition, pollutants are very likely to interrupt retinal development and function indirectly by disturbing the signaling of retinoids and thyroid. However, exact mechanisms of visual toxicity are largely unknown currently. In this review, the development and structure of retina and available tools for studying visual science are described briefly. Advances in visual toxicology are summarized in detail and outlooks for future visual toxicity studies are discussed. |
| WOS关键词 | DECABROMODIPHENYL ETHER BDE-209 ; POLYBROMINATED DIPHENYL ETHERS ; LONG-TERM EXPOSURE ; EARLY-LIFE STAGES ; PIKE ESOX-LUCIUS ; ZEBRAFISH LARVAE ; DEVELOPMENTAL TOXICITY ; EMBRYONIC EXPOSURE ; SUBLETHAL EXPOSURE ; DIETARY EXPOSURE |
| 资助项目 | National Natural Science Foundation of China[31971236] ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ03] |
| WOS研究方向 | Marine & Freshwater Biology ; Toxicology |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000551630500011 |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/36870]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 通讯作者 | Chen, Lianguo |
| 作者单位 | Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Lianguo. Visual system: An understudied target of aquatic toxicology[J]. AQUATIC TOXICOLOGY,2020,225:12. |
| APA | Chen, Lianguo.(2020).Visual system: An understudied target of aquatic toxicology.AQUATIC TOXICOLOGY,225,12. |
| MLA | Chen, Lianguo."Visual system: An understudied target of aquatic toxicology".AQUATIC TOXICOLOGY 225(2020):12. |
入库方式： OAI收割
来源：水生生物研究所
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