Nano-TiO2 enhanced bioaccumulation and developmental neurotoxicity of bisphenol a in zebrafish larvae
文献类型：期刊论文
| 作者 | Fu, Juanjuan1,2; Guo, Yongyong2; Yang, Lihua2; Han, Jian2; Zhou, Bingsheng2 |
| 刊名 | ENVIRONMENTAL RESEARCH
 |
| 出版日期 | 2020-08-01 |
| 卷号 | 187页码:8 |
| 关键词 | Bisphenol A n-TiO2 Co-exposure Bioaccumulation Neurotoxicity Zebrafish larvae |
| ISSN号 | 0013-9351 |
| DOI | 10.1016/j.envres.2020.109682 |
| 通讯作者 | Han, Jian(hanjian@ihb.ac.cn) |
| 英文摘要 | The titanium dioxide nanoparticles (n-TiO2) could enhance the bioavailability and toxicity of the coexisted organic toxicants in aquatic phase. Parental co-exposure to n-TiO2 and bisphenol A (BPA) could generate developmental neurotoxicity in unexposed zebrafish offspring. However, it remains unexplored regarding the developmental neurotoxicity in larvae fish after co-exposure during the early developmental stage. In present study, fertilized zebrafish eggs were exposed to TiO2 nanoparticles (100 mu g/L), BPA (1, 4 and 20 mu g/L) or their binary mixtures until 6 days post fertilization (dpf). No significant change was observed in hatching, malformation, survival and weight of the larvae among all groups. However, n-TiO2 significantly increased the body burden of BPA in the 4 and 20 mu g/L co-exposure groups, depressed expression of neurodevelopment marker genes (al-tubulin, mbp and syn2a) as well as the locomotor behavior. The current results indicate that n-TiO2 could strengthen the developmental neurotoxicity and inactive locomotion in co-exposed zebrafish larvae by promoting the bioaccumulation and bioavailability of BPA, which highlighted the similar toxic risks of developmental neurotoxicity after co-exposure at early developmental stage to that of the parental co-exposure. |
| WOS关键词 | TITANIUM-DIOXIDE NANOPARTICLES ; THYROID ENDOCRINE DISRUPTION ; NEURONAL DEVELOPMENT ; ENVIRONMENTAL LEVELS ; HUMAN HEALTH ; EXPOSURE ; BIOCONCENTRATION ; TOXICITY ; NANOMATERIALS ; EXPRESSION |
| 资助项目 | National Natural Science Foundation of China[21976207] ; National Natural Science Foundation of China[21806091] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ03] |
| WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health |
| 语种 | 英语 |
| WOS记录号 | WOS:000541251900063 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/38394]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 通讯作者 | Han, Jian |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Juanjuan,Guo, Yongyong,Yang, Lihua,et al. Nano-TiO2 enhanced bioaccumulation and developmental neurotoxicity of bisphenol a in zebrafish larvae[J]. ENVIRONMENTAL RESEARCH,2020,187:8. |
| APA | Fu, Juanjuan,Guo, Yongyong,Yang, Lihua,Han, Jian,&Zhou, Bingsheng.(2020).Nano-TiO2 enhanced bioaccumulation and developmental neurotoxicity of bisphenol a in zebrafish larvae.ENVIRONMENTAL RESEARCH,187,8. |
| MLA | Fu, Juanjuan,et al."Nano-TiO2 enhanced bioaccumulation and developmental neurotoxicity of bisphenol a in zebrafish larvae".ENVIRONMENTAL RESEARCH 187(2020):8. |
入库方式： OAI收割
来源：水生生物研究所
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