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Zebrafishprmt3negatively regulates antiviral responses

文献类型：期刊论文

作者Zhu, Junji5,6; Liu, Xing3,4,5; Cai, Xiaolian5,6; Ouyang, Gang3,4,5; Zha, Huangyuan2,5; Zhou, Ziwen5,6; Liao, Qian5,6; Wang, Jing3,4,5; Xiao, Wuhan1,3,4,5,6
刊名FASEB JOURNAL
出版日期2020-07-08
页码16
ISSN号0892-6638
关键词GCRV innate immunity prmt3 SVCV zebrafish
DOI10.1096/fj.201902569R
通讯作者Xiao, Wuhan(w-xiao@ihb.ac.cn)
英文摘要Arginine methylation catalyzed by protein arginine methyltransferases (PRMT) is a common post-translational modification in histone and nonhistone proteins, which regulates many cellular functions. Protein arginine methyltransferase 3 (prmt3), a type I arginine methyltransferase, has been shown to carry out the formation of stable monomethylarginine as an intermediate before the establishment of asymmetric dimethylarginine. To date, however, the role of PRMT3 in antiviral innate immunity has not been elucidated. This study showed that zebrafishprmt3was upregulated by virus infection and that the overexpression ofprmt3suppressed cellular antiviral response. The PRMT3 inhibitor, SGC707, enhanced antiviral capability. Consistently,prmt3-null zebrafish were more resistant to Spring Viremia of Carp Virus (SVCV) and Grass Carp Reovirus (GCRV) infection. Further assays showed that the overexpression ofprmt3diminished the phosphorylation of irf3 and prmt3 interacted with rig-i. In addition, both zinc-finger domain and catalytic domain of prmt3 were required for the suppressive function ofprmt3on IFN activation. Our findings suggested that zebrafishprmt3negatively regulated the antiviral responses, implicating the vital role ofprmt3-or even arginine methylation-in antiviral innate immunity.
WOS关键词ARGININE N-METHYLTRANSFERASE ; INDUCIBLE GENE-I ; RIG-I ; SUBSTRATE-SPECIFICITY ; SPRING VIREMIA ; PRMT3 ; RECOGNITION ; METHYLATION ; RNA ; OLIGOMERIZATION
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA 24010308] ; National Natural Science Foundation of China[31721005] ; National Natural Science Foundation of China[31830101] ; National Natural Science Foundation of China[31671315] ; National Key R&D Program of China[2018YFD0900602]
WOS研究方向Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
语种英语
出版者WILEY
WOS记录号WOS:000547819100001
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China
源URL[http://ir.ihb.ac.cn/handle/342005/38460]  
专题水生生物研究所_水环境工程研究中心_期刊论文
通讯作者Xiao, Wuhan
作者单位1.Chinese Acad Sci, Inst Hydrobiol, Key Aquat Biodivers & Conservat, Wuhan, Peoples R China
2.Dalian Ocean Univ, Dalian, Peoples R China
3.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China
4.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Junji,Liu, Xing,Cai, Xiaolian,et al. Zebrafishprmt3negatively regulates antiviral responses[J]. FASEB JOURNAL,2020:16.
APA Zhu, Junji.,Liu, Xing.,Cai, Xiaolian.,Ouyang, Gang.,Zha, Huangyuan.,...&Xiao, Wuhan.(2020).Zebrafishprmt3negatively regulates antiviral responses.FASEB JOURNAL,16.
MLA Zhu, Junji,et al."Zebrafishprmt3negatively regulates antiviral responses".FASEB JOURNAL (2020):16.

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来源：水生生物研究所

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