Zebrafish phd3 Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity
文献类型：期刊论文
| 作者 | Yu, Guangqing; Li, Xiong; Zhou, Ziwen; Tang, Jinhua; Wang, Jing; Liu, Xing; Fan, Sijia; Ouyang, Gang; Xiao, Wuhan |
| 刊名 | JOURNAL OF IMMUNOLOGY
 |
| 出版日期 | 2020-08-15 |
| 卷号 | 205期号:4页码:1135-1146 |
| ISSN号 | 0022-1767 |
| DOI | 10.4049/jimmunol.1900902 |
| 通讯作者 | Xiao, Wuhan(w-xiao@ihb.ac.cn) |
| 英文摘要 | Prolyl hydroxylase domain (PHD)-containing enzyme 3 belongs to the Caenorhabditis elegans gene egl-9 family of prolyl hydroxylases, which has initially been revealed to hydroxylate hypoxia-inducible factor alpha (HIF-alpha) and mediate HIF-alpha degradation. In addition to modulating its target function by hydroxylation, PHD3 has been also shown to influence its binding partners' function independent of its prolyl hydroxylase activity. In this study, we report that overexpression of zebrafish phd3 suppresses cellular antiviral response. Moreover, disruption of phd3 in zebrafish increases the survival rate upon spring viremia of carp virus exposure. Further assays indicate that phd3 interacts with irf7 through the C-terminal IRF association domain of irf7 and diminishes K63-linked ubiquitination of irf7. However, the enzymatic activity of phd3 is not required for phd3 to inhibit irf7 transactivity. This study provides novel insights into phd3 function and sheds new light on the regulation of irf7 in retinoic acid-inducible gene I-like receptor signaling. |
| WOS关键词 | HYPOXIA-INDUCIBLE FACTORS ; NF-KAPPA-B ; I INTERFERON ; INFECTIOUS-DISEASES ; ADAPTER PROTEIN ; IFN ; EXPRESSION ; UBIQUITINATION ; INHIBITION ; HEART |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24010308] ; National Natural Science Foundation of China[31830101] ; National Natural Science Foundation of China[31721005] ; National Natural Science Foundation of China[31671315] ; National Key R&D Program of China[2018YFD0900602] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000558826900025 |
| 出版者 | AMER ASSOC IMMUNOLOGISTS |
| 资助机构 | Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/38700]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 通讯作者 | Xiao, Wuhan |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Innovat Acad Seed Design, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China 4.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Guangqing,Li, Xiong,Zhou, Ziwen,et al. Zebrafish phd3 Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity[J]. JOURNAL OF IMMUNOLOGY,2020,205(4):1135-1146. |
| APA | Yu, Guangqing.,Li, Xiong.,Zhou, Ziwen.,Tang, Jinhua.,Wang, Jing.,...&Xiao, Wuhan.(2020).Zebrafish phd3 Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity.JOURNAL OF IMMUNOLOGY,205(4),1135-1146. |
| MLA | Yu, Guangqing,et al."Zebrafish phd3 Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity".JOURNAL OF IMMUNOLOGY 205.4(2020):1135-1146. |
入库方式： OAI收割
来源：水生生物研究所
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