Probiotic modulation of perfluorobutanesulfonate toxicity in zebrafish: Disturbances in retinoid metabolism and visual physiology
文献类型：期刊论文
| 作者 | Hu, Chenyan1; Tang, Lizhu5,6; Liu, Mengyuan5,6; Lam, Paul K. S.3,4; Lam, James C. W.2; Chen, Lianguo6 |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2020-11-01 |
| 卷号 | 258页码:10 |
| ISSN号 | 0045-6535 |
| 关键词 | PFBS Probiotic Retinoid metabolism Visual physiology Antagonistic action Zebrafish |
| DOI | 10.1016/j.chemosphere.2020.127409 |
| 通讯作者 | Lam, James C. W.(jameslam@eduhk.hk) ; Chen, Lianguo(lchenam@ihb.ac.cn) |
| 英文摘要 | Perfluorobutanesulfonate (PFBS), an aquatic pollutant of emerging concern, is found to disturb gut microbiota, retinoid metabolism and visual signaling in teleosts, while probiotic supplementation can shape gut microbial community to improve retinoid absorption. However, it remains unknown whether probiotic bacteria can modulate the toxicities of PFBS on retinoid metabolism and visual physiology. In the present study, adult zebrafish were exposed for 28 days to 0,10 and 100 mu g/L PFBS, with or without dietary administration of probiotic Lactobacillus rhamnosus. Interaction between PFBS and probiotic was examined regarding retinoid dynamics (intestine, liver and eye) and visual stimuli transmission. PFBS single exposures remarkably inhibited the absorption of retinyl ester in female intestines, which were, however, restored by probiotic to normal status. Although coexposure scenarios markedly increased the hepatic storage of retinyl ester in females, mobilization of retinol was reduced in livers by single or combined exposures regardless of sex. In the eyes, transport and catalytic conversion of retinol to retinal and retinoic acid were interrupted by PFBS alone, which were efficiently antagonized by probiotic presumably through an indirect action. In response to the availability of retinal chromophore, transcriptions of opsins and arrestin genes were altered adaptively to control visual perception and termination. Neurotransmission across retina circuitry was changed accordingly, centering on epinephrine and norepinephrine. In summary, the present study found the efficient modulation of probiotic on retinoid metabolic disorders of PFBS pollution, which subsequently impacted visual signaling. A future work is warranted to provide mechanistic clues in retinoid interaction. (C) 2020 Elsevier Ltd. All rights reserved. |
| WOS关键词 | GUT MICROBIOME ; ACID SYNTHESIS ; VITAMIN-A ; PERFLUOROALKYL ; SUBSTANCES ; EXPOSURE ; PBDES ; PERFLUOROOCTANESULFONATE ; REPRODUCTION ; DISRUPTION |
| 资助项目 | National Natural Science Foundation of China[31971236] ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ03] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2020FB09] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000566446500117 |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/38784]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 通讯作者 | Lam, James C. W.; Chen, Lianguo |
| 作者单位 | 1.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430072, Peoples R China 2.Educ Univ Hong Kong, Dept Sci & Environm Studies, Hong Kong, Peoples R China 3.City Univ Hong Kong, Dept Chem, Kowloon, Hong Kong, Peoples R China 4.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Chenyan,Tang, Lizhu,Liu, Mengyuan,et al. Probiotic modulation of perfluorobutanesulfonate toxicity in zebrafish: Disturbances in retinoid metabolism and visual physiology[J]. CHEMOSPHERE,2020,258:10. |
| APA | Hu, Chenyan,Tang, Lizhu,Liu, Mengyuan,Lam, Paul K. S.,Lam, James C. W.,&Chen, Lianguo.(2020).Probiotic modulation of perfluorobutanesulfonate toxicity in zebrafish: Disturbances in retinoid metabolism and visual physiology.CHEMOSPHERE,258,10. |
| MLA | Hu, Chenyan,et al."Probiotic modulation of perfluorobutanesulfonate toxicity in zebrafish: Disturbances in retinoid metabolism and visual physiology".CHEMOSPHERE 258(2020):10. |
入库方式： OAI收割
来源：水生生物研究所
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