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Binary exposure to hypoxia and perfluorobutane sulfonate disturbs sensory perception and chromatin topography in marine medaka embryos

文献类型：期刊论文

作者Tang, Lizhu5,6; Liu, Mengyuan5,6; Hu, Chenyan4; Zhou, Bingsheng6; Lam, Paul K. S.2,3; Lam, James C. W.1; Chen, Lianguo6
刊名ENVIRONMENTAL POLLUTION
出版日期2020-11-01
卷号266页码:10
关键词PFBS Hypoxia Transcriptome Sensory system DNA remodeling Marine medaka embryo
ISSN号0269-7491
DOI10.1016/j.envpol.2020.115284
通讯作者Chen, Lianguo(lchenam@ihb.ac.cn)
英文摘要Perfluorobutane sulfonate (PFBS), an environmental pollutant of emerging concern, is previously shown to dynamically interact with hypoxia on aquatic developmental toxicities. However, the molecular mechanisms underlying the interaction remain unknown. In this follow-up study, marine medaka embryos were exposed to 0 and 3.3 mg/L of PFBS under normoxia (6.9 mg/L) or hypoxia (1.7 mg/L) condition till 15 days post-fertilization. High-throughput transcriptomic sequencing was employed to filter differentially expressed genes and provide mechanistic insight into interactive action between hypoxia and PFBS. The results showed that hypoxia alone and the coexposure paradigm were similarly potent to modify transcriptional profiles, with the majority of genes significantly down-regulated. In contrast, transcriptional toxicity of PFBS was relatively milder. Functional annotation analyses found that hypoxia and coexposure groups mainly impacted phototransduction signaling by decreasing the transcriptions of cyclic nucleotide-gated (CNG) cation channels and retinol transport genes. However, this study demonstrated the first toxicological evidence that toxic effects of PFBS targeted the perception of chemical stimulus through olfactory and gustatory receptors. The addition of PFBS moderately exacerbated the toxic actions of hypoxia, which largely shaped the transcriptional pattern of coexposure group. In addition, gene interactive networks were constructed for hypoxia and coexposure groups, underlining the increased chromatin deacetylation and methylation to epigenetically repress genome-wide transcriptional initiation. Overall, PFBS and hypoxia interact to interrupt the embryonic development of sensory systems, which may compromise the individual fitness and survival, especially during early life stages when precocious perception of food and escape from predators are essential. (C) 2020 Elsevier Ltd. All rights reserved.
WOS关键词SUBSTANCES PFASS ; FISH ; RESPONSES ; HYDROCARBON ; PEROPSIN ; LONG
资助项目Research Grants Council Theme-Based Research Scheme[T21-602/16-R] ; National Natural Science Foundation of China[31971236] ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology[2019FBZ03] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2020FB09]
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000571442500009
出版者ELSEVIER SCI LTD
资助机构Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology
源URL[http://ir.ihb.ac.cn/handle/342005/38909]  
专题水生生物研究所_水环境工程研究中心_期刊论文
通讯作者Chen, Lianguo
作者单位1.Educ Univ Hong Kong, Dept Sci & Environm Studies, Hong Kong, Peoples R China
2.City Univ Hong Kong, Dept Chem, Kowloon, Hong Kong, Peoples R China
3.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China
4.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430072, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
推荐引用方式
GB/T 7714		 Tang, Lizhu,Liu, Mengyuan,Hu, Chenyan,et al. Binary exposure to hypoxia and perfluorobutane sulfonate disturbs sensory perception and chromatin topography in marine medaka embryos[J]. ENVIRONMENTAL POLLUTION,2020,266:10.
APA Tang, Lizhu.,Liu, Mengyuan.,Hu, Chenyan.,Zhou, Bingsheng.,Lam, Paul K. S..,...&Chen, Lianguo.(2020).Binary exposure to hypoxia and perfluorobutane sulfonate disturbs sensory perception and chromatin topography in marine medaka embryos.ENVIRONMENTAL POLLUTION,266,10.
MLA Tang, Lizhu,et al."Binary exposure to hypoxia and perfluorobutane sulfonate disturbs sensory perception and chromatin topography in marine medaka embryos".ENVIRONMENTAL POLLUTION 266(2020):10.

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来源：水生生物研究所

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