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Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7

文献类型：期刊论文

作者Li, Zhi1,2,3,4,5; Fan, Sijia1,2,3,4,5; Wang, Jing2,3,4,5; Chen, Xiaoyun1,2,3,4,5; Liao, Qian1,2,3,4,5; Liu, Xing2,3,4,5; Ouyang, Gang2,3,4,5; Cao, Hong2,3,4,5; Xiao, Wuhan1,2,3,4,5
刊名JOURNAL OF IMMUNOLOGY
出版日期2020-10-01
卷号205期号:7页码:1897-+
ISSN号0022-1767
DOI10.4049/jimmunol.2000305
通讯作者Xiao, Wuhan(w-xiao@ihb.ac.cn)
英文摘要FBXO3, belongs to the F-box family of proteins, which has been reported to involve in host autoimmune and inflammatory responses by promoting its substrates for ubiquitylation. However, thus far, its physiological function in antiviral immunity remains elusive. In this study, we report that overexpression of zebrafish fbxo3 suppresses cellular antiviral responses. Moreover, disruption of fbxo3 in zebrafish increases the survival rate upon spring viremia of carp virus exposure. Further assays indicate that fbxo3 interacts with irf3/irf7 and specifically catalyzes K27-linked ubiquitination of irf3 and irf7, resulting in proteasomal degradation of irf3 and irf7. However, the F-box domain of fbxo3 is not required for fbxo3 to interact with irf3/irf7 and to inhibit transactivity of irf3 and irf7. This study provides novel insights into fbxo3 function and the underlying mechanisms. In addition, it sheds new light on the regulation of IFN-I signaling by F-box proteins.
WOS关键词KAPPA-B-ALPHA ; UBIQUITIN LIGASE ; POSTTRANSLATIONAL MODIFICATIONS ; SIGNALING PROTEIN ; ADAPTER PROTEIN ; INNATE ; BETA ; UBIQUITYLATION ; ACTIVATION ; PATHWAY
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24010308] ; National Natural Science Foundation of China[31830101] ; National Natural Science Foundation of China[31721005] ; National Natural Science Foundation of China[31671315] ; National Key Research and Development Program of China[2018YFD0900602]
WOS研究方向Immunology
语种英语
WOS记录号WOS:000574415200017
出版者AMER ASSOC IMMUNOLOGISTS
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China
源URL[http://ir.ihb.ac.cn/handle/342005/38921]  
专题水生生物研究所_水环境工程研究中心_期刊论文
通讯作者Xiao, Wuhan
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquaculture Dis Control, Minist Agr, Wuhan 430072, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
5.Chinese Acad Sci, Innovat Acad Seed Design, Wuhan 430072, Peoples R China
推荐引用方式
GB/T 7714		 Li, Zhi,Fan, Sijia,Wang, Jing,et al. Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7[J]. JOURNAL OF IMMUNOLOGY,2020,205(7):1897-+.
APA Li, Zhi.,Fan, Sijia.,Wang, Jing.,Chen, Xiaoyun.,Liao, Qian.,...&Xiao, Wuhan.(2020).Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7.JOURNAL OF IMMUNOLOGY,205(7),1897-+.
MLA Li, Zhi,et al."Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7".JOURNAL OF IMMUNOLOGY 205.7(2020):1897-+.

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来源：水生生物研究所

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