中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity

文献类型:期刊论文

作者Yu, Guangqing4,5; Liu, Xing5; Zhang, Dawei5; Wang, Jing5; Ouyang, Gang5; Chen, Zhu3; Xiao, Wuhan1,2,4,5,6
刊名DEVELOPMENT
出版日期2020-09-01
卷号147期号:18页码:14
关键词Nedd8 Zebrafish Androgen receptor Ovary Testis Neddylation
ISSN号0950-1991
DOI10.1242/dev.194886
通讯作者Xiao, Wuhan(w-xiao@ihb.ac.cn)
英文摘要Nedd8 is a ubiquitin-like protein that covalently conjugates to target proteins through neddylation. In addition to cullin-RING ligases, neddylation also modifies non-cullin proteins to regulate protein activity, stability and localization. However, the roles of NEDD8 remain largely unknown in vivo. Here, we found that loss of nedd8 in female zebrafish led to defects in oogenesis, disrupted oocyte maturation and stimulated growth of the breeding tubercles (BTs) on the pectoral fins. The BTs are normally present in males, not females. However, the loss of one copy of ar can partially rescue the phenotypes displayed by nedd8-null female zebrafish. Further assays indicated that Nedd8 conjugates to Ar and Ar is neddylated at lysine 475 and lysine 862. Moreover, Nedd8 conjugation efficiently suppressed Ar transcriptional activity. Lysine 862 (K862) of Ar is the key site modified by neddylation to modulate Ar transcriptional activity. Thus, our results not only demonstrated that Nedd8 modulates ovarian maturation and the maintenance of female secondary sexual characteristics of female zebrafish in vivo, but also indicated that androgen signaling is strictly regulated by nedd8.
WOS关键词GERM-CELL DIFFERENTIATION ; POSTTRANSLATIONAL MODIFICATION ; PROTEIN NEDDYLATION ; SELF-RENEWAL ; PROSTATE ; REGENERATION ; EXPRESSION ; CANCER ; TESTES ; DEN1
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24010308] ; National Natural Science Foundation of China[31830101] ; National Natural Science Foundation of China[31721005] ; National Natural Science Foundation of China[31671315] ; National Natural Science Foundation of China[31701074] ; National Key Research and Development Program of China Stem Cell and Translational Research[2018YFD0900602]
WOS研究方向Developmental Biology
语种英语
WOS记录号WOS:000576692300019
出版者COMPANY BIOLOGISTS LTD
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China Stem Cell and Translational Research ; National Key Research and Development Program of China Stem Cell and Translational Research ; National Key Research and Development Program of China Stem Cell and Translational Research ; National Key Research and Development Program of China Stem Cell and Translational Research ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China Stem Cell and Translational Research ; National Key Research and Development Program of China Stem Cell and Translational Research ; National Key Research and Development Program of China Stem Cell and Translational Research ; National Key Research and Development Program of China Stem Cell and Translational Research ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China Stem Cell and Translational Research ; National Key Research and Development Program of China Stem Cell and Translational Research ; National Key Research and Development Program of China Stem Cell and Translational Research ; National Key Research and Development Program of China Stem Cell and Translational Research ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China Stem Cell and Translational Research ; National Key Research and Development Program of China Stem Cell and Translational Research ; National Key Research and Development Program of China Stem Cell and Translational Research ; National Key Research and Development Program of China Stem Cell and Translational Research
源URL[http://ir.ihb.ac.cn/handle/342005/38955]  
专题水生生物研究所_水环境工程研究中心_期刊论文
通讯作者Xiao, Wuhan
作者单位1.Chinese Acad Sci, Innovat Acad Seed Design, Wuhan 430072, Peoples R China
2.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan 430072, Peoples R China
3.Maternal & Child Hlth Hosp Hubei Prov, Dept Reprod, Wuhan 430070, Peoples R China
4.Univ Chinese Acad Sci, Dept Fisheries, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
6.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
推荐引用方式
GB/T 7714
Yu, Guangqing,Liu, Xing,Zhang, Dawei,et al. Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity[J]. DEVELOPMENT,2020,147(18):14.
APA Yu, Guangqing.,Liu, Xing.,Zhang, Dawei.,Wang, Jing.,Ouyang, Gang.,...&Xiao, Wuhan.(2020).Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity.DEVELOPMENT,147(18),14.
MLA Yu, Guangqing,et al."Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity".DEVELOPMENT 147.18(2020):14.

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来源:水生生物研究所

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