Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity
文献类型：期刊论文
| 作者 | Shi Chuang11; Lu Yao11; Zhai Gang11; Huang Jianfei11; Shang Guohui11; Lou Qiyong11; Li Dongliang10; Jin Xia11; He Jiangyan11; Du Zhenyu10 |
| 刊名 | Journal of Molecular Cell Biology
 |
| 出版日期 | 2020 |
| 卷号 | 12期号:4页码:291 |
| ISSN号 | 1674-2788 |
| 关键词 | anabolic metabolism HPI axis pomca somatic growth stress response |
| 英文摘要 | The endocrine regulatory roles of the hypothalamic-pituitary-adrenocortical axis on anxiety-like behavior and metabolic status have been found throughout animal taxa. However, the precise effects of the balancing adrenal corticosteroid biosynthesis under the influence of adrenocorticotrophic hormone(ACTH), a pro-opiomelanocortin(POMC)-derived peptide, on animal energy expenditure and somatic growth remain unknown. POMC has also been identified as one of the candidate loci for polycystic ovary syndrome, which features hyperandrogenism and some prevalence of obesity in patients. Here we show that zebrafish lacking functional POMCa exhibit similar phenotypes of stress response and body weight gain but not obesity as observed in mammalian models. In contrast with the impaired anorexigenic signaling cascade of melanocyte-stimulating hormones and leptin, which are responsible for their obesity-prone weight gain observed in various pomc mutant mammals, analyses with our pomca mutant series indicate that ACTH is the key regulator for the phenotype with enhanced somatic growth without obesity in pomca-deficient zebrafish. Hypocortisolism associated with hyperandrogenism has been observed in the pomcα-deficient zebrafish, with enhanced activation of mammalian target of rapamycin complex 1; reutilization of amino acids and fatty acid β-oxidation are observed in the muscle tissue of the pomca-deficient fish. After reducing hyperandrogenism by crossing our pomca mutant fish with a cyp17a1-deficient background, the phenotype of enhanced somatic growth in pomca-deficient fish was no longer observed. Thus, our work also demonstrated that the role of POMCa in stress response seems to be conserved in vertebrates, whereas its effect on adipostasis is unique to teleosts. |
| 语种 | 英语 |
| WOS记录号 | WOS:000547594100005 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/37661]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 作者单位 | 1.Institute of Hydrobiology,Chinese Academy of Sciences 2.School of Life Sciences,East China Normal University 3.Institute of Hydrobiology,Chinese Academy of Sciences 4.Institute of Hydrobiology,Chinese Academy of Sciences 5.School of Life Sciences,East China Normal University 6.Institute of Hydrobiology,Chinese Academy of Sciences 7.Institute of Hydrobiology,Chinese Academy of Sciences 8.Institute of Hydrobiology,Chinese Academy of Sciences 9.Institute of Hydrobiology,Chinese Academy of Sciences 10.Institute of Hydrobiology,Chinese Academy of Sciences |
| 推荐引用方式 GB/T 7714 | Shi Chuang,Lu Yao,Zhai Gang,et al. Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity[J]. Journal of Molecular Cell Biology,2020,12(4):291. |
| APA | Shi Chuang.,Lu Yao.,Zhai Gang.,Huang Jianfei.,Shang Guohui.,...&Yin Zhan.(2020).Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity.Journal of Molecular Cell Biology,12(4),291. |
| MLA | Shi Chuang,et al."Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity".Journal of Molecular Cell Biology 12.4(2020):291. |
入库方式： OAI收割
来源：水生生物研究所
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