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  2. 水生生物研究所
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  4. 水生生物分子与细胞生物学研究中心
  5. 期刊论文
ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling

文献类型：期刊论文

作者Sun, Xiaoyun4; Peng, Xixia3,4; Cao, Yuqin3,4; Zhou, Yan2; Sun, Yuhua1,3,4
刊名NATURE COMMUNICATIONS
出版日期2020-06-12
卷号11期号:1页码:16
ISSN号2041-1723
DOI10.1038/s41467-020-16799-0
通讯作者Sun, Yuhua(sunyh@ihb.ac.cn)
英文摘要ADNP (Activity Dependent Neuroprotective Protein) is a neuroprotective protein whose aberrant expression has been frequently linked to neural developmental disorders, including the Helsmoortel-Van der Aa syndrome (also called the ADNP syndrome). However, its role in neural development and pathology remains unclear. Here, we show that ADNP is required for neural induction and differentiation by enhancing Wnt signaling. Mechanistically, ADNP functions to stabilize beta -Catenin through binding to its armadillo domain which prevents its association with key components of the degradation complex: Axin and APC. Loss of ADNP promotes the formation of the degradation complex and beta -Catenin degradation via ubiquitin-proteasome pathway, resulting in down-regulation of key neuroectoderm developmental genes. In addition, adnp gene disruption in zebrafish leads to defective neurogenesis and reduced Wnt signaling. Our work provides important insights into the role of ADNP in neural development and the pathology of the Helsmoortel-Van der Aa syndrome caused by ADNP gene mutation. ADNP has been connected to neural developmental disorders. Here, the authors uncover a role for ADNP in neural induction and differentiation via beta -Catenin stabilization, with ADNP disruption in zebrafish leading to defective neurogenesis and decreased Wnt signaling.
WOS关键词DEPENDENT NEUROPROTECTIVE PROTEIN ; BETA-CATENIN ; SELF-RENEWAL ; STEM-CELLS ; PLURIPOTENCY ; CHROMATIN ; MUTATIONS ; INTERACTS ; BRAIN ; NAP
资助项目National Key Research and Development Program[2016YFA0101100] ; National Natural Science Foundation of China[31671526] ; Hundred-Talent Program (CAS)[Y623041501] ; Hundred-Talent Program (IHB)[Y623041501]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000542758700014
资助机构National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (CAS) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB) ; Hundred-Talent Program (IHB)
源URL[http://ir.ihb.ac.cn/handle/342005/38384]  
专题水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
通讯作者Sun, Yuhua
作者单位1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
2.Wuhan Univ, Frontier Sci Ctr Immunol & Metab, Med Res Inst, Wuhan 430071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Innovat Seed Design, Wuhan 430072, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Xiaoyun,Peng, Xixia,Cao, Yuqin,et al. ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling[J]. NATURE COMMUNICATIONS,2020,11(1):16.
APA Sun, Xiaoyun,Peng, Xixia,Cao, Yuqin,Zhou, Yan,&Sun, Yuhua.(2020).ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling.NATURE COMMUNICATIONS,11(1),16.
MLA Sun, Xiaoyun,et al."ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling".NATURE COMMUNICATIONS 11.1(2020):16.

入库方式： OAI收割

来源：水生生物研究所

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