中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 水生生物研究所
  3. 中科院水生所知识产出（2009年前）
  4. 水生生物分子与细胞生物学研究中心
  5. 期刊论文
Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis

文献类型：期刊论文

作者Shi, Lixia3,4; Wang, Nenghan3,4; Hu, Xudong3,4; Yin, Dacong1; Wu, Chenxi4; Liang, Huifang2; Cao, Wenxuan4; Cao, Hong4
刊名ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
出版日期2020-08-01
卷号78页码:11
ISSN号1382-6689
关键词Rare minnow Pb(2+)acute toxicity Histopathology Mitochondria
DOI10.1016/j.etap.2020.103385
通讯作者Cao, Hong(regancao@ihb.ac.cn)
英文摘要Lead (Pb) is a toxic heavy metal that can cause significant damage to the aquatic ecosystem. In this study, acute toxicity test of lead in rare minnow (Gobiocypris rarus) was conducted. The average LC50 for 96 h of Pb2+ is 423.01 mu g/L (95 % CI: 338.41-531.92 mu g/L). The order of bioaccumulation of Pb2+ was gills>kidney>intestine>liver>muscle>brain. A number of cellular and tissue alterations were observed in the gill, liver, kidney and intestine tissues of Pb2+-treated rare minnows through the histological examination performed by H&E and TEM analyses. Furthermore, we investigated the Pb2+-induced toxicity mechanisms in rare minnow based on transcriptome analyses, and a panel of immune-related genes were identified and evaluated by real-time quantitative PCR. In summary, our work indicates that rare minnow could be a valuable model for studying the mechanisms of lead acute toxicity in fish.
WOS关键词PEARL RIVER ESTUARY ; HEAVY-METAL ; IMMUNE-RESPONSES ; RAINBOW-TROUT ; LIVER ; FISH ; WATER ; GILL ; MODEL ; BIOACCUMULATION
资助项目CRSRI Open Research Program[SN: CKWV2017533/KY]
WOS研究方向Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
语种英语
出版者ELSEVIER
WOS记录号WOS:000549174200004
资助机构CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program ; CRSRI Open Research Program
源URL[http://ir.ihb.ac.cn/handle/342005/38548]  
专题水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
通讯作者Cao, Hong
作者单位1.Changjiang River Sci Res Inst, Wuhan 430010, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hepat Surg Ctr, Wuhan 430030, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
推荐引用方式
GB/T 7714		 Shi, Lixia,Wang, Nenghan,Hu, Xudong,et al. Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2020,78:11.
APA Shi, Lixia.,Wang, Nenghan.,Hu, Xudong.,Yin, Dacong.,Wu, Chenxi.,...&Cao, Hong.(2020).Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,78,11.
MLA Shi, Lixia,et al."Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 78(2020):11.

入库方式： OAI收割

来源：水生生物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。