Transport of Ciliary Membrane Proteins
文献类型：期刊论文
| 作者 | Long, Huan1,2,3; Huang, Kaiyao2 |
| 刊名 | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
 |
| 出版日期 | 2020-01-13 |
| 卷号 | 7页码:9 |
| 关键词 | cilia ciliary membrane protein diffusion barrier ciliary ectosome ciliopathies |
| ISSN号 | 2296-634X |
| DOI | 10.3389/fcell.2019.00381 |
| 通讯作者 | Huang, Kaiyao(huangky@ihb.ac.cn) |
| 英文摘要 | Cilia and flagella are highly conserved organelles in eukaryotic cells that drive cell movement and act as cell antennae that receive and transmit signals. In addition to receiving and transducing external signals that activate signal cascades, cilia also secrete ciliary ectosomes that send signals to recipient cells, and thereby mediate cell-cell communication. Abnormal ciliary function leads to various ciliopathies, and the precise transport and localization of ciliary membrane proteins are essential for cilium function. This review summarizes current knowledge about the transport processes of ciliary membrane proteins after their synthesis at the endoplasmic reticulum: modification and sorting in the Golgi apparatus, transport through vesicles to the ciliary base, entrance into cilia through the diffusion barrier, and turnover by ectosome secretion. The molecular mechanisms and regulation involved in each step are also discussed. Transport of ciliary membrane proteins is a complex, precise cellular process coordinated among multiple organelles. By systematically analyzing the existing research, we identify topics that should be further investigated to promote progress in this field of research. |
| WOS关键词 | PRIMARY CILIUM ; EXTRACELLULAR VESICLES ; PROTEOMIC ANALYSIS ; TRANSITION ZONE ; CHLAMYDOMONAS-REINHARDTII ; COUPLED RECEPTORS ; GOLGI-COMPLEX ; TRAFFICKING ; RAB8 ; MECHANISMS |
| 资助项目 | National Natural Science Foundation of China[31671399] ; National Natural Science Foundation of China[31401154] ; Chinese Government Scholarship |
| WOS研究方向 | Cell Biology ; Developmental Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000559266600001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship ; Chinese Government Scholarship |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/38690]  |
| 专题 | 水生生物研究所_藻类生物学及应用研究中心_期刊论文 |
| 通讯作者 | Huang, Kaiyao |
| 作者单位 | 1.Univ Calif Berkeley, Dept Plant Biol, Berkeley, CA 94720 USA 2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan, Peoples R China 3.Univ Calif Berkeley, Dept Microbial Biol, Berkeley, CA 94720 USA |
| 推荐引用方式 GB/T 7714 | Long, Huan,Huang, Kaiyao. Transport of Ciliary Membrane Proteins[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2020,7:9. |
| APA | Long, Huan,&Huang, Kaiyao.(2020).Transport of Ciliary Membrane Proteins.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,7,9. |
| MLA | Long, Huan,et al."Transport of Ciliary Membrane Proteins".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 7(2020):9. |
入库方式： OAI收割
来源：水生生物研究所
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