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  5. 期刊论文
The spectrin-based membrane skeleton is asymmetric and remodels during neural development in C. elegans

文献类型：期刊论文

作者Jia, Ru1,4; Chai, Yongping1,4; Xie, Chao1,4; Liu, Gai3; Zhu, Zhiwen1,4; Huang, Kaiyao3; Li, Wei2; Ou, Guangshuo1,4
刊名JOURNAL OF CELL SCIENCE
出版日期2020-08-01
卷号133期号:15页码:10
ISSN号0021-9533
关键词Cell migration Cytoskeleton Dendrite formation Membrane mechanics Spectrin Neural development
DOI10.1242/jcs.248583
通讯作者Li, Wei(weili_med@mail.tsinghua.edu.cn) ; Ou, Guangshuo(guangshuoou@tsinghua.edu.cn)
英文摘要Perturbation of spectrin-based membrane mechanics causes hereditary elliptocytosis and spinocerebellar ataxia, but the underlying cellular basis of pathogenesis remains unclear. Here, we introduced conserved disease-associated spectrin mutations into the Caenorhabditis elegans genome and studied the contribution of spectrin to neuronal migration and dendrite formation in developing larvae. The loss of spectrin resulted in ectopic actin polymerization outside of the existing front and secondary membrane protrusions, leading to defective neuronal positioning and dendrite morphology in adult animals. Spectrin accumulated in the lateral region and rear of migrating neuroblasts and redistributes from the soma into the newly formed dendrites, indicating that the spectrin-based membrane skeleton is asymmetric and remodels to regulate actin assembly and cell shape during development. We affinity-purified spectrin from C. elegans and showed that its binding partner ankyrin functions with spectrin. Asymmetry and remodeling of the membrane skeleton might enable spatiotemporal modulation of membrane mechanics for distinct developmental events.
WOS关键词ALPHA-SPECTRIN ; CELL-MIGRATION ; ACTIN ; MUTATIONS ; POLARITY
资助项目National Key R&D Program of China[2017YFA0503501] ; National Key R&D Program of China[2019YFA0508401] ; National Key R&D Program of China[2017YFA0102900] ; National Natural Science Foundation of China[31730052] ; National Natural Science Foundation of China[31525015] ; National Natural Science Foundation of China[31561130153] ; National Natural Science Foundation of China[31671444] ; National Natural Science Foundation of China[31871352]
WOS研究方向Cell Biology
语种英语
出版者COMPANY BIOLOGISTS LTD
WOS记录号WOS:000561047900022
资助机构National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
源URL[http://ir.ihb.ac.cn/handle/342005/38714]  
专题水生生物研究所_藻类生物学及应用研究中心_期刊论文
通讯作者Li, Wei; Ou, Guangshuo
作者单位1.Tsinghua Univ, MOE Key Lab Prot Sci, Beijing 100084, Peoples R China
2.Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China
4.Tsinghua Univ, Tsinghua Peking Ctr Life Sci, Beijing Frontier Res Ctr Biol Struct, McGovern Inst Brain Res,Sch Life Sci, Beijing 100084, Peoples R China
推荐引用方式
GB/T 7714		 Jia, Ru,Chai, Yongping,Xie, Chao,et al. The spectrin-based membrane skeleton is asymmetric and remodels during neural development in C. elegans[J]. JOURNAL OF CELL SCIENCE,2020,133(15):10.
APA Jia, Ru.,Chai, Yongping.,Xie, Chao.,Liu, Gai.,Zhu, Zhiwen.,...&Ou, Guangshuo.(2020).The spectrin-based membrane skeleton is asymmetric and remodels during neural development in C. elegans.JOURNAL OF CELL SCIENCE,133(15),10.
MLA Jia, Ru,et al."The spectrin-based membrane skeleton is asymmetric and remodels during neural development in C. elegans".JOURNAL OF CELL SCIENCE 133.15(2020):10.

入库方式： OAI收割

来源：水生生物研究所

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