中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The Proposed Neurotoxin beta-N-Methylamino-l-Alanine (BMAA) Is Taken up through Amino-Acid Transport Systems in the CyanobacteriumAnabaenaPCC 7120

文献类型:期刊论文

作者Wang, Zi-Qian2,3,4; Wang, Suqin2,3,4; Zhang, Ju-Yuan2,3; Lin, Gui-Ming2,3; Gan, Nanqin2,3; Song, Lirong2,3; Zeng, Xiaoli2,3; Zhang, Cheng-Cai1,2,3,5,6
刊名TOXINS
出版日期2020-08-01
卷号12期号:8页码:14
关键词neurodegenerative disease cyanobacteria amino acids transport BMAA resistance
DOI10.3390/toxins12080518
通讯作者Zeng, Xiaoli(zengxl@ihb.ac.cn) ; Zhang, Cheng-Cai(cczhang@ihb.ac.cn)
英文摘要Produced by cyanobacteria and some plants, BMAA is considered as an important environmental factor in the occurrence of some neurodegenerative diseases. Neither the underlying mechanism of its toxicity, nor its biosynthetic or metabolic pathway in cyanobacteria is understood. Interestingly, BMAA is found to be toxic to some cyanobacteria, making it possible to dissect the mechanism of BMAA metabolism by genetic approaches using these organisms. In this study, we used the cyanobacteriumAnabaenaPCC 7120 to isolate BMAA-resistant mutants. Following genomic sequencing, several mutations were mapped to two genes involved in amino acids transport, suggesting that BMAA was taken up through amino acid transporters. This conclusion was supported by the protective effect of several amino acids against BMAA toxicity. Furthermore, targeted inactivation of genes encoding different amino acid transport pathways conferred various levels of resistance to BMAA. One mutant inactivating all three major amino acid transport systems could no longer take up BMAA and gained full resistance to BMAA toxicity. Therefore, BMAA is a substrate of amino acid transporters, and cyanobacteria are interesting models for genetic analysis of BMAA transport and metabolism.
WOS关键词2,4-DIAMINOBUTYRIC ACID ; CYANOBACTERIAL NEUROTOXINS ; FRESH-WATER ; DAB ; GROWTH ; SEEDS
资助项目Key Research Program of Frontier Sciences of the Chinese Academy of Sciences[QYZDJ-SSW-SMC016] ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences[Y85Z061601] ; Chinese Academy of Sciences[Y65Z021501]
WOS研究方向Food Science & Technology ; Toxicology
语种英语
出版者MDPI
WOS记录号WOS:000564125300001
资助机构Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Featured Institute Service Projects from the Institute of Hydrobiology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences
源URL[http://ir.ihb.ac.cn/handle/342005/38717]  
专题水生生物研究所_藻类生物学及应用研究中心_期刊论文
通讯作者Zeng, Xiaoli; Zhang, Cheng-Cai
作者单位1.Chinese Acad Sci, Innovat Acad Seed Design, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Aix Marseille Univ, Inst AMU WUT, Wuhan 430072, Peoples R China
6.Wuhan Univ Technol, Wuhan 430072, Peoples R China
推荐引用方式
GB/T 7714
Wang, Zi-Qian,Wang, Suqin,Zhang, Ju-Yuan,et al. The Proposed Neurotoxin beta-N-Methylamino-l-Alanine (BMAA) Is Taken up through Amino-Acid Transport Systems in the CyanobacteriumAnabaenaPCC 7120[J]. TOXINS,2020,12(8):14.
APA Wang, Zi-Qian.,Wang, Suqin.,Zhang, Ju-Yuan.,Lin, Gui-Ming.,Gan, Nanqin.,...&Zhang, Cheng-Cai.(2020).The Proposed Neurotoxin beta-N-Methylamino-l-Alanine (BMAA) Is Taken up through Amino-Acid Transport Systems in the CyanobacteriumAnabaenaPCC 7120.TOXINS,12(8),14.
MLA Wang, Zi-Qian,et al."The Proposed Neurotoxin beta-N-Methylamino-l-Alanine (BMAA) Is Taken up through Amino-Acid Transport Systems in the CyanobacteriumAnabaenaPCC 7120".TOXINS 12.8(2020):14.

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来源:水生生物研究所

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