Functional characterization of a group II interferon, IFNc in the perciform fish, Nile tilapia (Oreochromis niloticus)
文献类型：期刊论文
| 作者 | Gan, Zhen1,2,4,5,6,7; Cheng, Jun2,5,6,7; Chen, Shannan1; Laghari, Zubair Ahmed1; Hou, Jing1,2,4,5,6,7; Xia, Liqun2,5,6,7; Lu, Yishan2,5,6,7; Nie, Pin1,3 |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 105页码:86-94 |
| ISSN号 | 1050-4648 |
| 关键词 | Oreochromis niloticus Type I interferon Interferon-stimulated genes Tyrosine phosphorylation Antiviral activity |
| DOI | 10.1016/j.fsi.2020.06.036 |
| 通讯作者 | Lu, Yishan(fishdis@163.com) ; Nie, Pin(pinnie@ihb.ac.cn) |
| 英文摘要 | Interferons are a family of class II alpha-helical cytokines playing vital roles in antiviral immune response, and little information is available to date regarding the interferon system of tilapia. In this study, a type I IFN gene, named On-IFNc, was identified in Nile tilapia, Oreochromis niloticus. The predicted protein of On-IFNc contains several structural features known in type I IFNs, and On-IFNc was clustered together with the known IFNc in fish into a separated Glade in the phylogenetic tree. On-IFNc gene was constitutively expressed in all tissues examined, with the highest expression level observed in liver, and was rapidly induced in all organs/tissues tested following the stimulation of poly(I:C). In addition, recombinant On-IFNc has been proven to markedly induce the expression of the antiviral effectors, Mx and viperin, the signalling components, STAT1, STAT2, and IRF9, and the transcription factors, IRF3 and IRF7, as well as the tyrosine phosphorylation of STAT1 and STAT2 in fish cells. Furthermore, recombinant On-IFNc has been proven to possess antiviral activity against ISKNV. The present study thus contributes to a better understanding of the functional properties of the type I IFN system in tilapia. |
| WOS关键词 | KIDNEY NECROSIS VIRUS ; ATLANTIC SALMON ; MOLECULAR CHARACTERIZATION ; INFECTIOUS SPLEEN ; IMMUNE-RESPONSE ; RAINBOW-TROUT ; EXPRESSION ; GENES ; IDENTIFICATION ; DISTINCT |
| 资助项目 | National Natural Science Foundation of China (NSFC)[31320103913] ; China Agriculture Research System[CARS-46] ; special talent programme One Thing One Decision |
| WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000571888900004 |
| 资助机构 | National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision ; special talent programme One Thing One Decision |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/38893]  |
| 专题 | 水生生物研究所_其他_期刊论文 |
| 通讯作者 | Lu, Yishan; Nie, Pin |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Guangdong Ocean Univ, Shenzhen Inst, 3 Binhai 2nd Rd, Shenzhen 518120, Guangdong, Peoples R China 3.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China 4.Shenzhen Dapeng New Dist Sci & Technol Innovat Se, Shenzhen 518120, Peoples R China 5.Shenzhen Publ Serv Platform Evaluat Marine Econ A, Shenzhen 518120, Peoples R China 6.Guangdong Prov Engn Res Ctr Aquat Anim Hlth Asses, Shenzhen 518120, Peoples R China 7.Guangdong Ocean Univ, Coll Fishery, Zhanjiang 524025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gan, Zhen,Cheng, Jun,Chen, Shannan,et al. Functional characterization of a group II interferon, IFNc in the perciform fish, Nile tilapia (Oreochromis niloticus)[J]. FISH & SHELLFISH IMMUNOLOGY,2020,105:86-94. |
| APA | Gan, Zhen.,Cheng, Jun.,Chen, Shannan.,Laghari, Zubair Ahmed.,Hou, Jing.,...&Nie, Pin.(2020).Functional characterization of a group II interferon, IFNc in the perciform fish, Nile tilapia (Oreochromis niloticus).FISH & SHELLFISH IMMUNOLOGY,105,86-94. |
| MLA | Gan, Zhen,et al."Functional characterization of a group II interferon, IFNc in the perciform fish, Nile tilapia (Oreochromis niloticus)".FISH & SHELLFISH IMMUNOLOGY 105(2020):86-94. |
入库方式： OAI收割
来源：水生生物研究所
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