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ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4

文献类型：期刊论文

作者Sun, XiaoYun1; Yu, WenJun2; Li, Li3; Sun, YuHua1,2
刊名FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
出版日期2020-07-01
卷号8页码:16
关键词ADNP embryonic stem cells chromatin lineage-specifying genes BRG1 CHD4
ISSN号2296-634X
DOI10.3389/fcell.2020.00553
通讯作者Li, Li(li.li@mail.hzau.edu.cn) ; Sun, YuHua(sunyh@ihb.ac.cn)
英文摘要ADNP (Activity Dependent Neuroprotective Protein) is proposed as a neuroprotective protein whose aberrant expression has been frequently linked to rare neural developmental disorders and cancers, including the recently described neurodevelopmental Helsmoortel-Van der Aa syndrome. Recent studies have suggested that ADNP functions as an important chromatin regulator. However, how ADNP-regulated chromatin mechanisms control gene expression and stem cell fate commitment remains unclear. Here we show that ADNP interacts with two chromatin remodelers, BRG1 and CHD4. ADNP is required for proper establishment of chromatin accessibility, nucleosome configuration, and bivalent histone modifications of developmental genes. Loss of ADNP leads to enhancer over-activation and increased ratio of H3K4me3/H3K27me3 at key primitive endoderm (PrE) gene promoters, resulting in prominent up-regulation of these genes and priming ES cell differentiation toward endodermal cell types. Thus, our work revealed a key role of ADNP in the establishment of local chromatin landscape and structure of developmental genes by association with BRG1 and CHD4. These findings provide further insights into the role of ADNP in the pathology of the Helsmoortel-Van der Aa syndrome.
WOS关键词DEPENDENT NEUROPROTECTIVE PROTEIN ; NUCLEOSOME OCCUPANCY ; SELF-RENEWAL ; COMPLEX ; PLURIPOTENCY ; DIFFERENTIATION ; SITES ; BRAIN ; CELLS
资助项目National Key Research and Development Program[2016YFA0101100] ; National Natural Science Foundation of China[31671526] ; CAS[Y623041501] ; NSFC[31771430] ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB[Y623041501]
WOS研究方向Cell Biology ; Developmental Biology
语种英语
WOS记录号WOS:000553060900001
出版者FRONTIERS MEDIA SA
资助机构National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS ; CAS ; CAS ; CAS ; NSFC ; NSFC ; NSFC ; NSFC ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB ; IHB ; IHB ; IHB ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS ; CAS ; CAS ; CAS ; NSFC ; NSFC ; NSFC ; NSFC ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB ; IHB ; IHB ; IHB ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS ; CAS ; CAS ; CAS ; NSFC ; NSFC ; NSFC ; NSFC ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB ; IHB ; IHB ; IHB ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS ; CAS ; CAS ; CAS ; NSFC ; NSFC ; NSFC ; NSFC ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; Huazhong Agricultural University Scientific & Technological Selfinnovation Foundation ; IHB ; IHB ; IHB ; IHB
源URL[http://ir.ihb.ac.cn/handle/342005/36876]  
专题水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
通讯作者Li, Li; Sun, YuHua
作者单位1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Peoples R China
2.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China
3.Huazhong Agr Univ, Coll Informat, Hubei Key Lab Agr Bioinformat, Wuhan, Peoples R China
推荐引用方式
GB/T 7714		 Sun, XiaoYun,Yu, WenJun,Li, Li,et al. ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2020,8:16.
APA Sun, XiaoYun,Yu, WenJun,Li, Li,&Sun, YuHua.(2020).ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,8,16.
MLA Sun, XiaoYun,et al."ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 8(2020):16.

入库方式： OAI收割

来源：水生生物研究所

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