Mediation of Mucosal Immunoglobulins in Buccal Cavity of Teleost in Antibacterial Immunity
文献类型：期刊论文
| 作者 | Xu, Hao-Yue2,3; Dong, Fen2; Zhai, Xue2; Meng, Kai-Feng2; Han, Guang-Kun2; Cheng, Gao-Feng2; Wu, Zheng-Ben2; Li, Nan1; Xu, Zhen2,3 |
| 刊名 | FRONTIERS IN IMMUNOLOGY
 |
| 出版日期 | 2020-09-23 |
| 卷号 | 11页码:14 |
| 关键词 | evolution mucosal immunoglobulins B-cells buccal mucosa bacterial infection |
| ISSN号 | 1664-3224 |
| DOI | 10.3389/fimmu.2020.562795 |
| 通讯作者 | Xu, Zhen(zhenxu@mail.hzau.edu.cn) |
| 英文摘要 | The buccal mucosa (BM) of vertebrates is a critical mucosal barrier constantly exposed to rich and diverse pathogens from air, water, and food. While mammals are known to contain a mucosal associated lymphoid tissue (MALT) in the buccal cavity which induces B-cells and immunoglobulins (Igs) responses against bacterial pathogens, however, very little is known about the evolutionary roles of buccal MALT in immune defense. Here we developed a bath infection model that rainbow trout experimentally exposed toFlavobacterium columnare(F. columnare), which is well known as a mucosal pathogen. Using this model, we provided the first evidence for the process of bacterial invasion in the fish BM. Moreover, strong pathogen-specific IgT responses and accumulation of IgT(+)B-cells were induced in the buccal mucus and BM of infected trout withF. columnare. In contrast, specific IgM responses were for the most part detected in the fish serum. More specifically, we showed that the local proliferation of IgT(+)B-cells and production of pathogen-specific IgT within the BM upon bacterial infection. Overall, our findings represent the first demonstration that IgT is the main Ig isotype specialized for buccal immune responses against bacterial infection in a non-tetrapod species. |
| WOS关键词 | RAINBOW-TROUT ; COLUMNARIS DISEASE ; ORAL-CAVITY ; B-CELLS ; IGA ; ZEBRAFISH ; FLAVOBACTERIUM ; INFECTION ; ISOTYPE ; PATHWAY |
| 资助项目 | National Key Research and Development Program of China[2018YFD0900400] ; National Natural Science Foundation of China[31873045] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000575619500001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/38927]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 通讯作者 | Xu, Zhen |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China 2.Huazhong Agr Univ, Coll Fisheries, Dept Aquat Anim Med, Wuhan, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Hao-Yue,Dong, Fen,Zhai, Xue,et al. Mediation of Mucosal Immunoglobulins in Buccal Cavity of Teleost in Antibacterial Immunity[J]. FRONTIERS IN IMMUNOLOGY,2020,11:14. |
| APA | Xu, Hao-Yue.,Dong, Fen.,Zhai, Xue.,Meng, Kai-Feng.,Han, Guang-Kun.,...&Xu, Zhen.(2020).Mediation of Mucosal Immunoglobulins in Buccal Cavity of Teleost in Antibacterial Immunity.FRONTIERS IN IMMUNOLOGY,11,14. |
| MLA | Xu, Hao-Yue,et al."Mediation of Mucosal Immunoglobulins in Buccal Cavity of Teleost in Antibacterial Immunity".FRONTIERS IN IMMUNOLOGY 11(2020):14. |
入库方式： OAI收割
来源：水生生物研究所
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