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Zebrafish RBM47 Promotes Lysosome-Dependent Degradation of MAVS to Inhibit IFN Induction

文献类型：期刊论文

作者Lu, Long-Feng2,3; Zhang, Can2,4; Zhou, Xiao-Yu2,5; Li, Zhuo-Cong2,4; Chen, Dan-Dan2,3; Zhou, Yu2,4; Zhou, Fang2; Zhang, Yong-An1; Li, Shun2,3
刊名JOURNAL OF IMMUNOLOGY
出版日期2020-10-01
卷号205期号:7页码:1819-+
ISSN号0022-1767
DOI10.4049/jimmunol.1901387
通讯作者Li, Shun(bob@ihb.ac.cn)
英文摘要IFN is essential for hosts to defend against viral invasion, whereas it must be tightly regulated to prevent hyperimmune responses. Fish mitochondrial antiviral signaling protein (MAVS) is a vital factor for IFN production, but until now, there have been few studies on the regulation mechanisms of fish MAVS enabling IFN to be properly controlled. In this study, we show that zebrafish RNAbinding motif protein 47 (RBM47) promotesMAVS degradation in a lysosome-dependent manner to suppress IFN production. First, the transcription of IFN activated by polyinosinic/polycytidylic acid (poly I:C), spring viremia of carp virus, or retinoic acid-inducible gene I (RIG-I)-like receptor pathway components were significantly suppressed by RBM47. Second, RBM47 interacted with MAVS and promoted lysosome-dependent degradation of MAVS, changing the cellular location of MAVS from the cytoplasm to the lysosome region. Finally, RBM47 inhibited downstream MITA and IRF3/7 activation, impairing the host antiviral response. Collectively, these data suggest that zebrafish RBM47 negatively regulates IFN production by promoting lysosome-dependent degradation of MAVS, providing insights into the role of RBM47 in the innate antiviral immune response in fish.
WOS关键词PATTERN-RECOGNITION RECEPTORS ; ANTIVIRAL SIGNALING PROTEIN ; RNA-BINDING PROTEIN ; RIG-I ; ADAPTER PROTEIN ; TARGETING MAVS ; INTERFERON ; ACTIVATION ; IRF3 ; GENE
资助项目National Key Research and Development Program of China[2018YFD0900504] ; Youth Innovation Promotion Association ; National Natural Science Foundation of China[31802338]
WOS研究方向Immunology
语种英语
WOS记录号WOS:000574415200010
出版者AMER ASSOC IMMUNOLOGISTS
资助机构National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
源URL[http://ir.ihb.ac.cn/handle/342005/38918]  
专题水生生物研究所_分析测试中心_期刊论文
通讯作者Li, Shun
作者单位1.Huazhong Agr Univ, Coll Fisheries, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
3.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian 116023, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan 430070, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Long-Feng,Zhang, Can,Zhou, Xiao-Yu,et al. Zebrafish RBM47 Promotes Lysosome-Dependent Degradation of MAVS to Inhibit IFN Induction[J]. JOURNAL OF IMMUNOLOGY,2020,205(7):1819-+.
APA Lu, Long-Feng.,Zhang, Can.,Zhou, Xiao-Yu.,Li, Zhuo-Cong.,Chen, Dan-Dan.,...&Li, Shun.(2020).Zebrafish RBM47 Promotes Lysosome-Dependent Degradation of MAVS to Inhibit IFN Induction.JOURNAL OF IMMUNOLOGY,205(7),1819-+.
MLA Lu, Long-Feng,et al."Zebrafish RBM47 Promotes Lysosome-Dependent Degradation of MAVS to Inhibit IFN Induction".JOURNAL OF IMMUNOLOGY 205.7(2020):1819-+.

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来源：水生生物研究所

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